Cellular Ageing and Replicative Senescence, 1st ed. 2016 Healthy Ageing and Longevity Series, Vol. 4
Coordonnateurs : Rattan Suresh I.S., Hayflick Leonard
Preface
Section I History and origins
Chapter 1: Origins of the Hayflick system, the phenomenon and the limit. (an interview by Suresh I.S. Rattan)
Chapter 2: Experimental foundations of the Hayflick system. (an interview by Suresh I.S. Rattan)
Section II Serial passaging and progressive changes
Chapter 3: Slowing down of the cell cycle during fibroblast proliferation. by: Alvaro Macieira-Coelho
Chapter 4: Influence of donor age and species longevity on replicative cellular senescence. by: Lorenzini and Andrea B. Maier
Chapter 5: Ageing of the stem cells: the conjoined twosome growing old –stem cell and its niche. by: Günter Lepperdinger
Chapter 6: Ageing and senescence in immune cells in vitro and in vivo. by: Graham Pawelec and Yvonne Barnett
Chapter 7: Telomere shortening – a mere replicometer? by: Stella Victorelli and Joao Passos
Chapter 8: Modelling cellular ageing: mathematical and computational approaches. by: Tarynn M. Witten
Section III AGEING, CANCER and sen
escenceChapter 9: Cell cycle checkpoints and senescence. by:Renu Wadhwa, Zeenia Kaul and Sunil C. Kaul
Chapter 10: Mitochondrial reactive oxygen species in cellular senescence. by: Timothy Nacarelli, Claudio Torres and Christian Sell
Chapter 11: Cellular aging and tumour regulation. by: Andreas Simm, Barbara Seliger and Lars-Oliver Klotz
Chapter 12:
Biomarkers of replicative senescence revisited. by: Jan NehlinSection IV AGEING ModulatORS
Chapter 13: Stress-induced (premature) senescence. by: Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaireand Olivier Toussaint
Chapter 14: Implications of cellular senescence on aging and disease in the brain. by:
Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell and Claudio TorresChapter 15: Small non coding RNAs in senescence and aging. by: Joseph Dhahbi
Chapter 16: Targeting senescent cells to improve huan health by: Tobias Wijshake and Jan M. A. van Deursen
Section V RECAPITULATION AND FUTURE EXPECTATIONS
Chapter 17: Unlike the stochastic events that determine ageing, sex determines longevity. by: Leonard Hayflick
Index
Provides a review of historical development of ideas in cellular ageing and replicative senescence
Presents a discussion of ageing and cancer in cell proliferation regulation
Explains usage of the cellular ageing model system for testing ageing modulators or anti-ageing compounds
Offers practical suggestions for future research and development in human health and disease
Includes supplementary material: sn.pub/extras
Date de parution : 05-2016
Ouvrage de 364 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 105,49 €
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Mots-clés :
Ageing; Cancer; Cell cycle regulation; Longevity; Stress; cytogenetics