Biotargets of Cancer in Current Clinical Practice, 2012 Current Clinical Pathology Series

Biotargets of Cancer in Current Clinical Practice presents an updated and reasoned review of the current status of knowledge concerning the major cancer types with a special focus on the current biomarkers, genes involved and the potential future targets of innovative therapies. The volume includes for each major cancer type, a comprehensive although concise discussion of epidemiology, affirmed and innovative biomarkers for diagnosis, and descriptions of the relevant genes for prognosis and (individualized) therapy through biotarget-specific new molecular treatments, with the latest information on the validation status of each novel biomarker. Individual chapters are dedicated to the major cancer types, plus a special chapter on metastasis. The present debate on patentability of genetic information applied to diagnostics and therapeutics of cancer is also discussed.

Central Nervous System Tumors.- Head and Neck Tumors.- Thyroid Cancer.- Targeted Therapies for Non-Small Cell Lung Cancer.- Non-Hodgkin Lymphomas.- Leukemias.- Breast Cancer.- Esophago-Gastric Cancer.- Colorectal Cancer.- Hepatocellular Carcinoma.- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma.- Bladder Cancer.- Biomarkers in Prostate cancer.- Ovarian Cancer.- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer.- Biotargets in Sarcomas: The Past, Present and a Look into the Future.- Melanoma and other skin cancers.- Molecular pathology of cancer metastasis: suggestions for future therapy.- Current and future developments in cancer therapy research: miRNAs as new promising targets or tools.

Mauro Bologna, MD
University of L’Aquila, L’Aquila, Italy

Provides the latest information on the validation status of each novel biomarker Covers the present debate on potential clinical use of newly discovered biochemical markers and on patentability of genetic information Chapter authors are experts on the particular cancer type