Acute Respiratory Distress Syndrome, Softcover reprint of the original 1st ed. 1998 Cellular and Molecular Mechanisms and Clinical Management NATO Science Series A: Series, Vol. 297

Proceedings of a NATO ASI held in Corfu, Greece, June 15-25, 1997

SECTION 1: SODIUM (Na+) TRANSPORT AND FLUID CLEARANCE ACROSS THE NORMAL AND INJURED LUNGS.- Regulation of the Sodium Pump in Hyperoxic Lung Injury.- Lung Edema Clearance during Hyperoxic Lung Injury.- The Role of Lung Lymphatics in Pulmonary Edema Clearance.- Molecular Biology of Lung Na+ Absorption.- Regulation of Alveolar Sodium Transport by Hypoxia.- Vectorial Movement of Sodium in Lung Alveolar Epithelium: Role and Regulation of Na+,K-ATPase.- The Premature Infant’s Inability to Clear Fetal Lung Liquid Results in Respiratory Distress Syndrome (RDS).- Role of Matrix Macromolecules in Controlling Lung Fluid Balance: Transition from a Dry Tissue to Edema**.- Role of the Na+-K+-ATPase ?2 Subunit in Lung Liquid Clearance**.- Aveolar Epithelial Fluid Transport under Normal and Pathological Conditions.- SECTION 2: ROLE OF THE PULMONARY SURFACTANT IN THE PATHOGENESIS AND TREATMENT OF ARDS.- Host Defense Capacities of Pulmonary Surfactant.- Alterations of Pulmonary Surfactant in ARDS—Pathogenic Role and Therapeutic Perspectives.- Surfactant Replacement in Patients with ARDS: Results of Clinical Trials.- Potential Role for Pulmonary Surfactant in Lung Transplantation.- Preparation of Surfactant and Lipid Vectors for Delivery of Proteins and Genes to Tissue.- Recombinant SP-C Based Surfactant Can Improve Lung Function in Saline Lavaged Sheep**.- SECTION 3: MECHANISMS AND MODIFICATION OF ACUTE AND CHRONIC LUNG INJURY.- Gene Therapy for the Acute Respiratory Distress Syndrome.- The Use of Recombinant Antioxidants in Neonatal Respiratory Distress Syndrome.- The Early Inflammatory Response in Acute Respiratory Distress Syndrome (ARDS).- The N-Nitroso-N-Methylurethane Induced Acute Lung Injury Animal Model for ARDS: Minireview.- Hyperoxia Induced Fibrosis in ARDS and Bpd:Current Pathology and Cytokine Profiles.- MAP Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science.- Oxidant-Regulated Gene Expression in Inflammatory Lung Disease.- Pulmonary Edema of Mixed or Incompletely Understood Pathogenesis.- Biologic Markers of Acute Lung Injury.- Pathways to Oxidative Cell Death.- Divergent Effects of Hypoxia and Oxidants on Mitochondrial Superoxide Dismutase (MnSOD) Gene Expression.- Cellular Sources of Cytokines in Pulmonary Fibrosis.- Strategies to Speed Lung Healing in ARDS.- Pulmonary Microvascular Occlusion in Aggregate Anaphylaxis**.- The Expression of ICAM-1 and P-Selectin Are Increased following Hemorrhage and Resuscitation in Mice**.- Increased Levels of Markers of Protein Oxidation in Bronchoalveolar Lavage Fluid from Patients with ARDS**.- SECTION 4: VENTILATORY STRATEGIES FOR THE MANAGEMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS).- The Use of PEEP in the Treatment of ARDS.- Tracheal Gas Insufflation.- Mechanical Ventilation in ARDS: Good or Bad News?.- Ventilator-Induced Lung Injury in Patients with ARDS.- Mechanical Ventilation for ARDS: Should We Reduce Tidal Volume?.- Endotracheal Tube Resistance and Passive Expiratory Time during Mechanical Ventilation in ARDS.- Use of Liquid Ventilation in Animal Models of ARDS.- Inhaled Prostacyclin for the Treatment of ARDS.- Is There Improvement in the Prognosis of ARDS?.- Effect of Ventilation Strategy on Cytokine Expression in an ex Vivo Lung Model**.- Abnormal Tissue Oxygenation and Cardiovascular Changes in Endotoxaemia: Beneficial Effects of Volume Resuscitation**.- SECTION 5: NITRIC OXIDE: FRIEND AND FOE.- Mechanisms of Nitric Oxide Induced Injury to the Alveolar Epithelium.- Macrophage Killing of Mycoplasmas: Involvement of Surfactant Protein A and Nitric Oxide.- Exhaled Nitric Oxide in Patients Undergoing Cardiothoracic Surgery: A New Diagnostic Tool?.- ARDS: Nitric Oxide as Cause and Therapy in Multiple Organ Failure (MOF).- Role of Reactive Nitrogen Species in Asbestos-Induced Pleuro-Pulmonary Injury.- Biomarkers of Oxidative Stress in Adult Respiratory Distress Syndrome.- Reactive Oxygen and Nitrogen Species and Adult Respiratory Distress Syndrome (ARDS): New Mechanisms to Be Considered.- SECTION 6: HEALTH CARE LEGISLATION.- Health and Science Legislation in the United States.