Contemporary Topics in Immunobiology, Softcover reprint of the original 1st ed. 1978 Volume 8

In this current volume of Contemporary Topics in Immunobiology we have chosen to continue with the multiple-theme approach that was developed in Volumes 1, 3, and 5 of this series. Immunobiology still shows little sign of decreasing its active growth rate, but rather is continuing to broaden its range of interests and applications, particularly as new techniques and methods are adapted from other fields of medical research. This present volume reflects both several of the more classical areas of immunology now addressed in the light of contemporary immunology, and several newer directions that have been taken in other fields. The general subject of T-cell heterogeneity and functions of T-cell subpop­ ulations is addressed in Chapters 1 and 2. The potential role of genes of the major histocompatibility complex in controlling the immune functions of T lymphocytes still remains a major unresolved issue in immunogenetics, and the current status of this problem is excellently reviewed by J. F. A. P. Miller. The further elucidation of functional subpopulations of human T lymphocytes has been particularly hampered by the lack of available markers for character­ izing and isolating such sUbpopulations. A major step in this direction has been made by L. Moretta, M. Ferrarini, and M. D. Cooper, who review their ex­ perience with Fc-receptor-bearing human T-Iymphocyte populations.

1 Influence of Genes of the Major Histocompatibility Complex on theReactivity of Thymus-Derived Lymphocytes.- I. Introduction.- II. Constraints Imposed on T-Cell Activities by Genes of the Major Histocompatibility Complex.- III. Implications of MHC-Imposed Restrictions for Antigen Perception by T Lymphocytes.- IV.MHC-Linked Ir Gene Control of Immune Responsiveness.- V.Relationship between MHC-Imposed Constraints and MHC-Linked Ir Gene Control of Immune Responsiveness.- VI.Concluding Remarks.- VII.References.- 2 Characterization of Human T-Cell Subpopulations as Defined by Specific Receptors for Immunoglobulins.- I. Introduction.- II. Basic Features of Distinct T-Cell Subpopulations and Their Receptors for Immunoglobulins.- III. Functional Analysis of T.M and T.G Cells.- IV. T.M and T.G Cells in Immunodeficiency Diseases and Malignancies.- V. Concluding Remarks and Speculations.- VI. References.- 3 Metazoan and Protozoan Parasitic Infections in Nude Mice.- I. Introduction.- II. Nematodes.- III. Cestodes.- IV. Trematodes.- V. Protozoa.- VI. Concluding Remarks.- VII. References.- 4 In Vitro Induction and Expression of T-Cell Immunity to Tumor-Associated Antigens.- I. Introduction.- II. Methodology.- III. Induction of CL in “Unstimulated” Cultures.- IV. Role of theMHC at theInductive Phase of T-Cell Immunity in Vitro to TAA.- V. Role of theMHC at theEffector Phase of Tc Immunity in Vitro to TAA.- VI. Comments and Conclusions.- VII. References.- 5 Systemic and Local Immunity in Allograft and Cancer Rejection.- I. Introduction.- II. Histology of Allograft Rejection and Host Response against Solid Tumors.- III. Effector Mechanisms in the Central Lymphatic System.- IV. Isolation of Infiltrating Cells and Antibodies from Allografts and Tumors.- V. Identification ofInfiltrating Cells in Allografts and Tumors.- VI. Effector Mechanisms Inside Allografts and Tumors.- VII. Correlations between Local and Systemic Immunity.- VIII. Concluding Remarks.- IX. References.- 6 Natural Killer Cells in theMouse: An Alternative Immune Surveillance Mechanism?.- I. Introduction.- II. General Characteristics of theNK System.- III. Specificity of Mouse NK Cytolytic Activity.- IV. Effector Cell Analysis.- VI. Influence of Genetic and Nongenetic Factors on NK Activity.- VI. Relationship between NK Activity and Resistance to Hemopoietic Grafts.- VII. Generation of NK Cells in Vivo.- VIII. Concluding Remarks.- IX. References.- 7 Allotypes of IgM and IgD Receptors in theMouse: A Probe for Lymphocyte Differentiation.- I. Lymphocyte Surface Immunoglobulin.- II. Preparation of Antisera to Murine IgD.- III. Allotypes of Murine IgM.- IV. Immunofluorescence Studies of Surface IgM and IgD.- V. Implications for Organization of Immunoglobulin Heavy-Chain Genes.- VI. Functional Role of B-Cell Receptors.- VII. Summary.- VIII. References.- 8 Immunoglobulin Isotype Expression.- I. Introduction.- II. Ontogeny of Immunoglobulin Isotypes.- III. In Vitro Activation of Mouse B Cells.- IV. Conclusions.- V. References.