The Neuroscience of Deep Brain Stimulation Research and Clinical Applications

Deep Brain Stimulation (DBS) is an established and successful treatment options for patients with movement disorders, including Parkinson's disease, dystonia, and some psychiatric conditions. Neuroscience of Deep Brain Stimulation: Research and Clinical Applications, begins by introducing readers to the foundational research and historical background of DBS, including developmental experimental models for movement and psychiatric disorders. The second section reviews various clinical applications including numerous and in-depth case studies. The final section identifies the mechanisms of action behind DBS, including cellular, metabolic and neurochemical mechanisms. Internationally contributed, this book will become the essential guide for anyone in the field of DBS.

Part 1: Bench
1. The quest for a target and the beginning of the DBS-story
2. Early clinical application
3. Development of experimental models for movements disorders
4. Development of experimental models for psychiatric disorders

Part 2: Science behind the clinical application
5. Parkinson’s disease
6. Dystonia
7. Essential tremor
8. Epilepsy
9. OCD
10. Tourette Syndrome
11. Depression
12. Alzheimer’s disease
13. Other indications

Part 3: Mechanisms of action
14. Neurophysiological mechanisms
15. Cellular mechanisms
16. Metabolic mechanisms
17. Neurochemical mechanisms
18. Mechanisms investigated by imaging

Part 4. Future/perspectives

Yasin Temel is a Professor of Neurosurgery, Medical Center in Maastricht University, Maastricht, The Netherlands.
Research Director Abdelhamid Benazzouz works in the Neurodegenerative Dis Institute, Bordeaux University, France.
Experienced academic researcher with a demonstrated history of working in the field of Neuromodulation and Neurodegenerative disorders. Head of functional neurosurgery section at the department of neurosurgery. Skilled in Fundamental Neuromodulation research and academic teaching, Neuroanatomy, Animal Models, Electrophysiology, Behavior, Stereology and Microscopy. Co-founder and coordinator of Neuromodulation Master Specialization at Maastricht University.