Neuropsychology of Cardiovascular Disease (2^nd Ed.)

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and most westernized nations. Both CVDs and their risk factors confer substantial risk for stroke and dementia, but are also associated with more subtle changes in brain structure and function and cognitive performance prior to such devastating clinical outcomes. It has been suggested that there exists a continuum of brain abnormalities and cognitive difficulties associated with increasingly severe manifestations of cardiovascular risk factors and diseases that precede vascular cognitive impairment and may ultimately culminate in stroke or dementia.

This second edition examines the relations of a host of behavioral and biomedical risk factors, in addition to subclinical and clinical CVDs, to brain and cognitive function. Associations with dementia and pre-dementia cognitive performance are reported, described, and discussed with a focus on underlying brain mechanisms. Future research agendas are suggested, and clinical implications are considered. The volume is a resource for professionals and students in neuropsychology, behavioral medicine, neurology, cardiology, cardiovascular and behavioral epidemiology, gerontology, geriatric medicine, nursing, adult developmental psychology, and for other physicians and health care professionals who work with patients with, or at risk for, CVDs.

Part I: Behavioral and Biomedical Risk Factcors 1. The Effects of Tobacco Smoke on Cognition and the Brain Gary E. Swan. and Christina N. Lessov-Schlagger 2. Alcohol Consumption, Brain, and Neurocognition Francesco Panza, Vincenza Frisardi, Davide Seripa, Alberto Pilotto, and Vincenzo Solfrizzi 3. Activity and Neurocognitive Health in Older Adults Michelle C. Carlson and Vijay R. Varma 4. Hypertension, Blood Pressure, and Cognitive Functioning Merrill F. Elias, Amanda F. Goodell, and Michael A. Robbins 5. Effects of Cholesterol and N-3 Fatty Acids on Cognitive Functioning, Decline, and Dementia Matthew F. Muldoon and Sarah M. Conklin 6. Cognition in Diabetes and Pre-Diabetes Stages Augustina M.A. Brands, Esther van den Berg, Geert Jan, Biessels, and Roy P.C. Kessels 7. Neurocognitive Aspects of Obesity Kelly M. Stanek, Lindsay A. Miller, and John Gunstad. 8. Inflammation Anna L. Marsland 9. Homocysteine, Folic Acid, B Vitamins, and Cognitive Functioning Georgina E. Crichton, Michael A. Robbins, and Merrill, F. Elias 10. Resting and Stress-Reactive Cortisol Nida Ali, Vincent Corbo, Laura Copeland, amd Jens C. Pruessner Part II: Cardiovascular Disease and Interventions 11. Subclinical Cardiovascular Disease and Neurocognition Carrington Rice Wendell, and Shari R. Waldstein 12. Clinical Cardiovascular Disease Nathalie Stroobant, Merrill, F. Elias, and Amanda F. Goodell 13. Coronary Artery Bypass Surgery Patrick J. Smith, Joseph P. Mathew, and James A. Blumenthal 14. Heart Failure and Cognitive Function Ronald A. Cohen and Karin F. HothPart III: Dementia and Stroke 15. Cardiovascular Risk Factors and Dementia Chengxuan Qiu and Laura Fratiglioni 16. Vascular Cognitive Impairment Jose G. Merino and Vladimir Hachinski 17. White Matter Disease, Stroke, and the Heterogeneity of Vascular Dementia Catherine C. Price, Peter Nguyen, Melissa Lamar, and David J. Libon 18. Structural Brain Mechanisms and Dementia Samuel N. Lockhart and Charles DeCarli

Shari R. Waldstein, PhD, is Professor of Psychology, Gerontology, and Medicine at the University of Maryland, Baltimore County and University of Maryland School of Medicine.

Merrill F. Elias, PhD, MPH, FAHA, is Professor of Psychology and Cooperating Professor, Graduate School of Biomedical Science and Engineering at the University of Maine.