Degenerative Disorders of the Brain

Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects.

Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer?s disease and other dementias, Parkinson?s disease and related disorders, and Huntington?s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation.

Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.

Acknowledgements

Foreword

Chapter 1 – Brain circuitry and ageing in neurodegenerative disease

Chapter 2 – Alzheimer’s Disease: Prodromal Stages and Dementia

Chapter 3 – Parkinson’s disease

Chapter 4 – Huntington’s disease

Chapter 5 – Experience-dependent modulation of neurodegenerative disorders: Huntington’s disease as an exemplar

Chapter 6 – Fragile X-associated tremor ataxia syndrome

Chapter 7 – Multiple sclerosis

Chapter 8 – Dementia with Lewy Bodies

Chapter9 – Motor Neuron Disease

Chapter10 – New clinical neuroscience technologies for treating neurodegenerative disorders

Chapter 11 – Conclusions and last thoughts

Darren R. Hocking is a Senior Research Fellow and ARC DECRA Fellow at La Trobe University, Australia.

John L. Bradshaw is Emeritus Professor of Neuropsychology at Monash University, Australia.

Joanne Fielding is Associate Professor in the Central Clinical School at Monash University, Australia.