Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

1. Fundamentals of Viruses and Their Proteases Anjana Sharma and Satya P. Gupta 2. Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies Noha Saleh Hanan Elhaes and Medhat Ibrahim 3. Advances in Studies on Adenovirus Proteases and Their Inhibitors Satya P. Gupta Basheerulla Shaik and Y. S. Prabhakar 4. Alpha-virus Nonstructural Proteases and Their Inhibitors Akalabya Bissoyi, Subrat KumarPattanayak Arindam Bit Ashish Patel, Abhishek 5. Structure and Function of Alphavirus Protease Shailly Tomar and Megha Aggarwal 6. Flavivirus Protease: An Antiviral Target Shailly Tomar, Rajat Mudgal and Benazir Fatma 7. Flavivirus NSB/NS3 Protease: Structure, Function, and Inhibition Zhong Li Jing Zhang Hongmin Li 8. Design and Development of HCV NS5B Polymerase Inhibitors Debasis Das 9. Studies on HIV-1 Protease and its Inhibitors Sonal Dubey 10. Studies on Picornaviral Proteases and Their Inhibitors Vaishali M. Patiland Satya P. Gupta 11. Structural Insight into the Viral 3C-like Protease inhibitors: Comparative SAR/QSAR Approaches Nilanjan Adhikari Sandip Kumar Baidya Achintya Saha, Tarun Jha 12. Herpesvirus Proteases: Structure, Function, and Inhibition Kriti Kashyap and Rita Kakkar 13. Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR Dimitra Hadjipavlou-Litina and Satya P Gupta 14. Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance Dolly A. Parasrampuria

Clinicians, researchers and academics in Virology, Microbiology/Immunology, and Molecular Biology, and medicinal chemistry

• Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition
• Analyzes structure-activity relationships of inhibitors of each viral protease
• Presents an in-depth view of the structure and function of viral proteases