Viral Polymerases Structures, Functions and Roles as Antiviral Drug Targets
Coordonnateur : Gupta Satya Prakash
Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs.
1. RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy 2. Structure-Function Relationship of Negative-Stranded Viral RNA Polymerases: Prospectives for Antiviral Therapy 3. RNA-Dependent RNA Polymerase of Alphaviruses: A Potential Target for the Design of Drugs Against Alphaviruses 4. DNA-dependent DNA Polymerases as Drug Targets in Herpesviruses and Poxviruses 5. Polio Virus Polymerase: An Effective Target for Design and Development of Anti-polio Drugs 6. Studies on HIV-1 Polymerase and its Inhibitors 7. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics 8. Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase: An Integral Part of HCV Antiviral Therapy 9. HBV Polymerase as a Target for Development of Anti-HBV Drugs 10. Polymerases of Coronaviruses: Structure, Function and Inhibitors 11. Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors 12. Herpes Virus Polymerase Inhibitors 13. Zika Virus Polymerase: Structure, Function and Inhibitors 14. Dengue Virus Polymerase: A Crucial Target for Anti-Viral Drug Discovery 15. Adenovirus DNA Polymerase: Structure, Function and Prospects in Diagnostics and Therapeutics
Clinicians,researchers and academics in Virology, Microbiology/Immunology, medicinal chemistry,drug design, biochemistry, enzyme chemistry, molecular biology
- Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition
- Analyzes the structure-activity relationships of inhibitors of each viral polymerase
- Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets
Date de parution : 11-2018
Ouvrage de 496 p.
15x22.8 cm
Thème de Viral Polymerases :
Mots-clés :
3DPol crystal structure; 3Dpol inhibitors; Adenovirus antivirals; Adenovirus diagnosis; Adenovirus replication; Adenoviruses; Allosteric inhibitors; Alphaviral diseases; Alphaviruses; Anti-HBV drugs; Antipolio drugs; Antiviral strategies; Antivirals; Atomistic-level modeling; Chikungunya; Coronavirus; Crystal structure; DENV RdRP; DNA polymerase; Direct-acting antivirals (DAAs); Drug design; Drug discovery; Drug resistance; Ebola virus; Encephalitis; Exonuclease; Falviviridae; Flavivirus; HBV genome; HBV life cycle; HBV mutants; HBV polymerase; HBV polymerase inhibitors; HBV replication; HSV polymerase; Hepatitis C virus (HCV); Hepatocellular carcinoma (HCC); Herpes simplex virus; Herpes simplex virus (HSV); Herpesvirus polymerase; Homology modeling; Human immunodeficiency virus; Inhibitor; Inhibitors; Interferon (IFN); L-protein; Middle East respiratory syndrome coronavirus; Molecular dynamics; Negative-strand RNA polymerase; Nonnucleoside inhibitors; Nonnucleoside/nonnucleotide inhibitors (NNIs); Nonsegmented genomes; Nonstructural (NS) protein; Nonstructural proteins; Nucleoside analogs; Nucleoside inhibitors; Nucleoside/nucleotide inhibitors (NIs); Picornaviridae; Polio; Polymerase inhibitors; Poxvirus polymerase; Protein-structure function; RNA polymerase; RNA polymerases; RNA replication; RNA-dependent RNA polymerase; RNA-dependent RNA polymerase (3Dpol); RNA-dependent RNA polymerases (RdRPs); RNase; Reverse transcriptase; Rhinovirus; Ribavirin (RBV); Segmented genomes; Severe acute respiratory syndrome coronavirus; Structure-based drug design; Vaccinia virus; Viral hemorrhagic fever; Viral polymerase; ZIKV polymerase; Zika virus
