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Umbilical Cord Blood Banking and Transplantation, Softcover reprint of the original 1st ed. 2014 Stem Cell Biology and Regenerative Medicine Stem Cell Biology and Regenerative Medicine Series

Langue : Anglais

Coordonnateur : Ballen Karen

Couverture de l’ouvrage Umbilical Cord Blood Banking and Transplantation
Despite significant improvements in outcomes after umbilical cord blood transplantations (UCBT), several challenges remain including delayed engraftment and immune recovery, contributing to a high rate of infections. Umbilical Cord Blood Banking and Transplantation, part of the Stem Cell Biology and Regenerative Medicine series, provides a detailed overview of this compelling topic. Optimal selection of the UCB unit is discussed in sections on maternal typing, the Cord Blood Apgar Score, HLA-C and the relationship between HLA and cell dose. Transplant outcomes for malignant and non malignant diseases are reviewed, from authors in North America, Europe, Japan, and the Middle East. Immune recovery is a major problem after UCBT and this topic is tackled with sections on T cell recovery. Strategies to improve survival in adults are analyzed in chapters on double cord blood, cord blood expansion, homing of the cord blood unit, and intramarrow administration. Finally, recent data and ongoing studies comparing UCB to unrelated bone marrow/peripheral blood stem cells and haploidentical donors are outlined. Overall, this volume comprehensively discusses the world wide scope of umbilical cord blood transplantation, including coverage of the recent controversies in public cord blood banking and of future developments towards improving outcomes.
1. Cord Blood Bank-New Techniques on Cord Blood Banking. 2. Quality Control in Cord Blood Banking. 3. New York Blood Center-Maternal Typing and Cord Blood Unit Choice. 4. Choice of the Optimal Cord Blood Unit. 5. Cord Blood Transplantation in Metabolic Disorders. 6. The Cord Blood Apgar and Choice of Cord Blood Unit. 7. Cord blood Transplantation in the Middle East. 8. Myeloablative Single Unit Cord Blood Transplantation. 9. Eurocord and Double vs Single Cord Blood Transplant. 10. Intra Marrow Injection of Cord Blood Unit. 11. Immune Recovery Following Double Cord Blood Transplantation. 12. HLA Typing and Cord Blood Unit Choice. 13. Combined Haplo and Cord Blood unit-Myeloablative. 14. Combined Haplo and Cord Blood-Reduced Intensity. 15. Notch expansion and Cord Blood. 16. Mesoblast Expansion and Cord Blood. 17. Homing Techniques in Cord Blood-Clinic Studies. 18. Homing Techniques in Cord Blood-Basic Studies. 19. Update in Double Cord Blood Transplantation. 20. TREC levels and Cord Blood Transplantation. 21. Studies comparing Haplo and Cord Blood. 22. Selection of the Optimal Graft Source.​

Dr. Karen Ballen received her MD at Dartmouth College and then completed an Internal Medicine internship and residency at Beth Israel Deaconess Medical Center, Boston, and a Hematology/Oncology fellowship at Brigham and Women's Hospital, Boston. She has held several attending physician appointments including Transplant Physician, Brigham and Women's Hospital and Children's Hospital, Boston; Director, Bone Marrow Transplant Unit, UMass Memorial Health Care; and Acting Division Director, Medical Oncology, UMass Memorial Health Care. Dr. Ballen is currently a Full Professor in the Department of Medicine, Harvard Medical School, and director of the leukemia program, Massachusetts General Hospital. Her research interests focus on novel therapies for leukemia and transplantation. A particular area of specialty is cord blood transplantation for those patients who do not have matched related or unrelated donors. Dr. Ballen’s research has focused on improving outcomes after cord blood transplantation, and she has led multiple clinical trials focusing on double cord blood transplantation in adults, cord blood homing strategies, graft vs. host disease prophylaxis and infection prophylaxis. She has authored more than 100 papers in this field.

Comprehensive and detailed overview of umbilical cord blood (UCB) transplantation from optimal selection of the UCB unit, transplant outcomes for malignant &, non-malignant diseases, and much more

Discusses significant related issues like recent controversies in public cord blood banking

Includes a section that focuses on future developments to improve outcomes

Date de parution :

Ouvrage de 286 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 138,03 €

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Date de parution :

Ouvrage de 286 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

179,34 €

Ajouter au panier
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