Tumor Vascularization

Langue : Anglais

Coordonnateurs : Ribatti Domenico, Pezzella Francesco

Couverture de l’ouvrage Tumor Vascularization

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Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.

1. Sprouting and non-sprouting angiogenesis in tumors2. Nonangiogenic tumor growth3. Vascular co-option4. Pericyte mimicry: an embryonic-like mechanism for tumor metastasis5. Vasculogenic mimicry6. Postnatal vasculogenesis7. The perivascular niche8. Zebrafish as an experimental model to study tumor angiogenesis9. Clinical implications

cancer researchers, medical scientists, clinicians, graduate students

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.

He has published many books with both Elsevier and Springe
Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.

Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels
Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences
Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment