Trafficking of GPCRs
Auteur : Wu Guangyu
G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.
- Arrestins: Critical Players in Trafficking of Many GPCRsVsevolod V. Gurevich and Eugenia V. Gurevich
- Regulation of GPCR Trafficking by UbiquitinJustine E. Kennedy and Adriano Marchese
- Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and MechanismsIna Nemet, Philip Ropelewski and Yoshikazu Imanishi
- Intracellular Trafficking of Neuropeptide Y ReceptorsKarin Mörl and Annette G. Beck-Sickinger
- Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and InternalizationMichèle Darmon, Sana Al Awabdh , Michel-Boris Emerit and Justine Masson
- Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of Interacting ProteinsKausik Ray
- Trafficking of ß Adrenergic Receptors: Implications in Intracellular Receptor SignalingQin Fu and Yang K. Xiang
- Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.Shanna L. Bowman and Manojkumar A. Puthenveedu
- a2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug ActionChristopher Cottingham, Craig J. Ferryman and Qin Wang
- Regulation of a2B-Adrenerigc Receptor Export Trafficking by Specific Motifs Guangyu Wu, Jason E. Davis and Maoxiang Zhang
- Temperature-Sensitive Intracellular Traffic of ?2c-Adrenergic ReceptorCatalin M. Filipeanu
- N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal TransductionClaudia Rutz, Wolfgang Klein and Ralf Schülein
- Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs Brent Young, Jaime Wertman and Denis J. Dupré
- Written by future leaders in the pain field
- Covers a wide range of targets
- Contains provocative ideas about GPCR trafficking
Date de parution : 06-2015
Ouvrage de 328 p.
15x22.8 cm