Streptococcus Pneumoniae Molecular Mechanisms of Host-Pathogen Interactions

Langue : Anglais

Coordonnateurs : Brown Jeremy, Hammerschmidt Sven, Orihuela Carlos

Couverture de l’ouvrage Streptococcus Pneumoniae

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Streptococcus Pneumoniae: Molecular Mechanisms of Host-Pathogen Interactions provides a comprehensive overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology.

It presents a state-of-the-art overview of the implications of existing data, along with the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections and how to combat these infections.

Users will find a timely update on the topic, as the dramatic increase in antibiotic resistance pneumoniae cases and limitations of the currently available pneumoniae vaccines are creating new concerns on these gram-positive bacteria that are endowed with a high virulence potential, and are the most common etiologic agent of respiratory and life-threatening invasive diseases.

Section A: Streptococcus pneumoniae Epidemiology and Vaccines 1. Pneumococcal molecular epidemiology 2. Antibiotic resistance of pneuomocci 3. Pneumococcal vaccination and consequences 4. Protein based vaccines

Section B: Genetics and Functional Genomics of Streptococcus pneumoniae 5. Genomics, genetic variation and regions of differences 6. Functional Genomics of pneumococci (Transcriptional regulation) 7. Pneumococcal genetic recombination during colonization and biofilm formation 8. The pneumococcal cell wall 9. Capsule structure, synthesis and regulation 10. Pneumococcal ABC transporters and their role in physiology and multidrug resistance

Section C: Streptococcus pneumoniae Biology 11. Structure and functions of surface protein/choline binding proteins 12. Pneumococcal non-adhesive surface proteins 13. Biofilm formation under in vitro conditions 14. Pneumolysin

Section D: Pneumococcal Interactions with the Host 15. Nasopharyngeal colonization 16. Otitis media and biofilms 17. Pneumococcal pili and adhesins 18. Exploitation of host signal transduction pathways induced by S. pneuomoniae 19. Mechanisms of predisposition to pneumonia: infants, the elderly, and viral infections 20. Mechanisms causing the inflammatory response to Streptococcus pneumoniae 21. Immune evasion mechanisms of pneumococci 22. Cell mediated adaptive immunity to pneumococci 23. Pneumococcal invasion

students, scientists and practitioners in micro and molecular biology, cell biology and immunology, any scientist working with or again Streptococcus pneumoniae, clinicians such as medical doctors on pulmonary diseases, infection biologists, public health scientists.

Jeremy Brown is a clinician scientist who is Professor of Respiratory Infection at University College London. He has 16 years experience in investigating the pathogenesis of Streptococcus pneumoniae infections, particularly the development of pneumonia. His main research interests are innate and adaptive immune responses to S. pneumoniae, new vaccine development, the role of ABC transporters during infection, and characterising the phenotypic consequences of genetic differences between S. pneumoniae strains. As well as leading his research group he works as a respiratory physician caring for patients with lung infections at University College London Hospitals. He is an editorial board member for Infection and Immunity, Pneumonia and the Journal of Infectious Diseases.
Sven Hammerschmidt is Professor and Head of the Department of Genetics of Microorganisms at the University of Greifswald in Germany. He is a microbiologist and molecular biologist, graduated 1996 from Medical Microbiology at the Medical School Hannover and University of Hannover in Germany followed by a postdoc time from 1996 to 2003 at the Helmholtz-Centre for Infection Research, Braunschweig, Germany. This time was associated with two short-term stays as a visiting scientist at the Menzies School of Health Research, Darwin, Northern Territory, Australia. In 2003 he was appointed as head of a young investigator group at the Center for Infection Research, University of Würzburg, Germany and In 2007 Sven Hammerschmidt was appointed as an associate professor for Cellular Microbiology at the Max von Pettenkofer-Institute for Hygiene and Medical Microbiology, University of Munich, Germany. In 2008 he moved to the University of Greifswald and became full-professor for General and Molecular Genetics. In 1998 he received the Robert Koch prize for post-docs and in 2008 the Becton Dickenson Research Award of the German Society of Hygiene and Microbiology (DGHM). His research interests are focused on deciphe

Provides an updated overview of our existing knowledge on Streptococcus pneumoniae antibiotic resistance, dissemination, and pathogenesis, including immunology
Helps strengthen interdisciplinary networking and the focus of scientific resources by targeting epidemiology, vaccines, genetics, antibiotic resistance, clonal dissemination, Streptococcus pneumoniae biology, functional genomics, inflammasome, biomarkers, and more
Multi-authored by leaders in the field who present a state-of-the-art overview of what the implications are of existing data, and the areas of research that are important for future insights into the molecular mechanisms of pneumococcal infections
Supports combinatory networking in order to find new solutions in clinical therapies
Reflects the most topical pneumococcal research trends