Spontaneous Pathology of the Laboratory Non-human Primate

Spontaneous Pathology of the Laboratory Non-human Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research.

Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors.

1. Introduction to 1st Edition
2. Choice of Primate species
3. Regulatory issues in the use of primates
4. Infectious Diseases
5. Clinical Examination
6. Salivary glands
7. Oral Cavity
8. Esophagus and Stomach
9. Small and Large Intestine
10. Liver
11. Exocrine Pancreas
12. Kidney
13. Urinary bladder, ureter, urethra
14. Brain
15. Spinal Cord and Nerves
16. Eye and associated glands
17. Skeletal Muscle
18. Bone and Joints
19. Skin and subcutis
20. Specialized sebaceous glands
21. Mammary Gland
22. Respiratory tract
23. Immune System
24. Bone Marrow
25. Female Reproductive Tract
26. Testis
27. Male sex glands
28. Heart
29. Blood Vessels
30. Thyroid
31. Parathyroid
32. Pituitary
33. Adrenal
34. Endocrine Pancreas
35. Hematology

Dr. Bradley has been with Charles River since 1998 where she is the senior director of pathology. In this capacity she leads a team of veterinary pathologists and pathology analysts. She has specialist interest and provides consultancy services in neuropathology, non-human primate pathology, medical devices, and cellular therapy products (human and animal stem cells). She is an experienced study pathologist for acute, long term reproductive toxicology, tumorigenicity, oncogenicity, microautoradiography, target animal safety and carcinogenicity studies. She has authored over 700 GLP or GMP compliant toxicological peer reviewed pathology and photomicroscopy reports. She is the GLP and GMP Study Director as well as the Quality Control Manager for GMP pathology services.
Dr. Chilton has been with Charles River since 2007 where she is the senior veterinary pathologist. She has specialist interest and provides consultancy services in neuropathology, non-human primate and comparative pathology. She has authored numerous GLP and investigative toxicological reports and is currently the neuropathology liaison to The National Chimpanzee Brain Resource (NCBR), George Washington University, Washington DC and staff pathologist for the Alamogordo Primate Facility, Alamogordo, NM.
Ms. Mahler is a Pathology Associate with over 32 years of experience as a certified histologist (HT) in the areas of histology, animal necropsy, and digital photomicroscopy. Since 2006, she has served as the illustrations editor for the journal Toxicologic Pathology. Past illustrative editorship roles include associate editor of Pathology of the Mouse, edited by Dr Robert R. Maronpot.