Sex Determination in Vertebrates

Sex Determination, Volume 134, the latest release in the Current Topics in Developmental Biology series, contains current reviews in the field of vertebrate sex determination. It covers molecular pathways of sex determination in genetic and environmental species and encompasses both sex determination of somatic lineages and commitment of germ cells to male or female fate. Chapters in this new release cover, amongst other topics, Mapping the Sox9 Enhancer Elements, Epigenetic Regulation of Sex Determination, Evolution and Management of Sex Chromosomes, Regulation of Germ Cell Sex Identity in Medaka, Control of Sex Determination in Zebrafish, Sexually Dimorphic Germ Cell Identity in Mammals, and more.

1. Evolution and meiotic organization of heteromorphic sex chromosomes Tasman Daish and Frank Grützner 2. Environmental regulation of sex determination in fishes: Insights from atheriniformes Yoji Yamamoto, Ricardo S. Hattori, Reynaldo Patiño and Carlos A. Strüssmann 3. Natural sex change in fish Neil J. Gemmell, Erica V. Todd, Alexander Goikoetxea, Oscar Ortega-Recalde and Timothy A. Hore 4. Genetic regulation of sex determination and maintenance in zebrafish (Danio rerio) Michelle E. Kossack and Bruce W. Draper 5. Regulation of germ cell sex identity in medaka Minoru Tanaka 6. Characterizing the bipotential mammalian gonad Serge Nef, Isabelle Stévant and Andy Greenfield 7. Role of epigenetic regulation in mammalian sex determination Shingo Miyawaki and Makoto Tachibana 8. The regulation of Sox9 expression in the gonad Nitzan Gonen and Robin Lovell-Badge 9. Sexually dimorphic germ cell identity in mammals Cassy Spiller and Josephine Bowles 10. Rethinking sex determination of non-gonadal tissues Arthur P. Arnold 11. Translating genomics to the clinical diagnosis of disorders/differences of sex development Abhinav Parivesh, Hayk Barseghyan, Emmanuèle Délot and Eric Vilain

Scientists interested in molecular mechanisms of fate specification; reproductive biologists interested in how the sexes are established.

• Contains reviews written by leading experts in each field
• Includes informative figures that illustrate principle points that are useful for teaching
• Written in a style that is clear and simple