Regenerative Nephrology (2^nd Ed.)

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

Section 1: Kidney Development and Regeneration

1. Nephrogenesis in Health and Disease

2. Renal organogenesis in the lymph node microenvironment

3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology

4. Nephrogenesis in malnutrition

Section 2: Modulators of Regeneration

5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease

6. T-cell in kidney injury and regeneration

7. Monocytes and dendritic cells in injury and regeneration

8. Mast cells in kidney regeneration

Section 3: Stem Cells in Regenerative Processes

9.Regeneration and replacement of endothelial cells and renal vascular repair

10. Stem cells in regenerative processes: Induced pluripotent stem cells

11. Nephroprotective effect of urine-derived stem cells for renal injury

12. Amniotic stem cells and their exosomes

13. Regenerative potential of stem-cell-derived extracellular vesicles

14. Stem cell therapies in diabetes

Section 4: Causes of Regenerative Failure

15. Progression of kidney disease as a maladaptive response to injury

16. Molecular mechanisms of cellular senescence

17. Characteristics of senescent cells

18. Stress-induced senescence of tubular cells

19. Stress-induced senescence as a forme fruste of chronic kidney disease- A case for failed regeneration

20. Premature vascular aging and senescence in chronic kidney disease

21. Injury and regeneration in renal aging

22. Gender-dependent mechanisms of injury and repair

Section 5: Kidney Engineering

23. Glomerular stem cells

24. Reconstitution of the kidney glomerular capillary wall

25. Microfluidic modeling of glomerulus and tubular appartus

26. Matrix scaffolds in kidney engineering

Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando

Section 6: Emerging Clinical Aspects of Regenerative Therapy

27. Reprogramming toward kidney regeneration: New technologies and future promises

28. Therapy cell reconditioning

29. Senomorphic, senolytic, and rejuvenation therapies

30. Natural products in regeneration Rachel B. Wilson, Jason J. Lee, Geoffrey Pickering, and Nica M. Borradaile 

31. Nanotargeting to the kidney

32. Small molecules in regeneration

33. Systems biology in diagnosis and reamtnet of kidney disease

34. Overview of ethical concerns raised by kidney organoids

35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies

Joshua Hunsberger and Sita Somara

• A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes
• A new section on tissue engineering of the kidney of interest to nephrologists and urologists
• An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies
• A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues