Regenerative Medicine: Laboratory to Clinic, 1st ed. 2017

This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering. It examines in detail the therapeutic application of hematopoietic stem cells in marrow regeneration, multi-potent mesenchymal stem cells (MSCs), also referred to as mesenchymal stromal cells. The interest in MSCs can be seen in more than 150 clinical trials, some of which have progressed to Phase III, despite the cells? limited differentiation potential. The book also explores how embryonic stem (ES) cells, being pluripotent in nature, can resolve some of the problems associated with adult stem cells, yet entail other challenges like risks of teratoma formation and immune rejection. A separate chapter deals with the role of noncoding RNAs in neuronal commitment of induced pluripotent stem (iPS) cells.

The book is broadly divided into two parts, the first of which is devoted to basic information on stem cells, and the second of which addresses potential clinical applications in the areas of hematology, cardiology, orthopedic and immune suppression, etc.

Physical forces that regulate stem cell fate.- Pluripotent stem cells: its potential applications.- Unraveling the role of long-non coding RNAs in pluripotent stem cells-based neuronal commitment and neurogenesis.- Control of quiescence in adult stem cells.- Etiology and treatment of osteoarthritis: A developmental biological perspective.- Differences in cell populations and expression of soluble mediators between normal wound healing and healing in the diabetic.- MSC-derived exosomes as tools in regenerative medicine.- Mixing of different batches of cells permits better therapeutic potential of MSCs.- Blood to blood: new candidate for regenerative medicine.- HSC based gene therapy for blood diseases.- Allogeneic stem cell transplantation including haplo-identical stem cell transplants.- Mesenchymal stem cells and transplantation tolerance.- Ideal stem cell candidate for regenerative medicine.- Pre-clinical/clinical study on idiopathic pulmonary fibrosis.- Comparative analysis between ES and iPS cells for use in regenerative medicine: scope, advantage and safety.- Regeneration of lacrimal gland: potential and progress.- Clinical trials in cardiac regeneration using adult stem cells: Current and future prospects.- Tissue engineering for the treatment of in large bone defect.- Corneal Regeneration: Current status and future directions.- Cell therapy for retinal regeneration: current progress and future challenges.- Vaculogenesis: Importance in regeneration of solid organs.- Cord blood banking in India and the global scenario.- Prospects and retrospect of clinical applications of stem cell in veterinary sciences.- Engineering of scaffolds for soft tissue engineering.- 3D bioprinting of tissue.- Tissue engineering: Cell, scaffold and growth factor based strategies.- Pre-clinical trial:  A bottleneck that impedes development of regenerative medicine.- Stem cell research work ethics and Indian stem cell research policy.

Dr. Asok Mukhopadhyay has just retired from the very prestigious National Institute of Immunology, New Delhi after more than 25 years of service as a Scientist & Principle Investigator. He received his PhD from the Indian Institute of Technology, New Delhi and worked as a Post-Doctoral Research Fellow at MD Anderson Cancer Center, Houston, Texas, USA. His main area of research is stem cells in regenerative medicine. He has published 75 research papers, contributed to 7 book chapters and has also written the textbook “Animal Cell Technology” [Published by IK International, New Delhi; ISBN: 978-81-89866-96-9 (2009)]. Further, he holds 2 Indian patents.