Protein Bioinformatics, 1st ed. 2017 From Protein Modifications and Networks to Proteomics Methods in Molecular Biology Series, Vol. 1558
Coordonnateurs : Wu Cathy H., Arighi Cecilia N., Ross Karen E.
This volume introduces bioinformatics research methods for proteins, with special focus on protein post-translational modifications (PTMs) and networks. This book is organized into four parts and covers the basic framework and major resources for analysis of protein sequence, structure, and function; approaches and resources for analysis of protein PTMs, protein-protein interactions (PPIs) and protein networks, including tools for PPI prediction and approaches for the construction of PPI and PTM networks; and bioinformatics approaches in proteomics, including computational methods for mass spectrometry-based proteomics and integrative analysis for alternative splice isoforms, for functional discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory or computational protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and thorough, Protein Bioinformatics: From Protein Modifications and Networks to Proteomics is a valuable resource for readers who wish to learn about state-of-the-art bioinformatics databases and tools, novel computational methods, and future trends in protein and proteomic data analysis in systems biology. This book is useful to researchers who work in the biotechnology and pharmaceutical industries, and in various academic departments, such as biological and medical sciences and computer sciences and engineering.
Preface...
Table of Contents...
Contributing Authors...
Part I Fundamentals of Protein Bioinformatics
1. Protein Bioinformatics Databases and Resources
2. UniProt Protein Knowledgebase
Sangya Pundir, Maria J. Martin, and Claire O’Donovan
4. CATH-Gene3D: Generation of the Resource and its Use in Obtaining Structural and Functional Annotations for Protein Sequences
5. Structure-Based Virtual Screening
Part II Protein PTM (Post-Translational Modification) Bioinformatics
6. Bioinformatics Analysis of Protein Phosphorylation in Plant Systems Biology Using P3DB
7. Navigating the Glycome Space and Connecting the Glycoproteome
8. Impact of Nonsynonymous Single-Nucleotide Variations on Post-Translational Modification Sites in Human Proteins