Progress in Molecular Biology and Translational Science Progress in Molecular Biology and Translational Science Series

Progress in Molecular Biology and Translational Science, Volume 160 provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series gives in-depth knowledge on the important molecular biological aspects of organismal physiology and function, along with insights on how this knowledge can be applied to understand and ameliorate human disease. This updated release covers Clinical Drugs in the Environment, Group I Intron Trans-Splicing, Adult Stem Cells on Regenerative Therapy, CRISPR in Animals and Animal Models, The Role of 3??5?Exoribonucleases in RNA Degradation, and more.

Preface David B. Teplow 1. Adult Stem Cells for Regenerative Therapy Narasimman Gurusamy, Abdulrhman Alsayari, Sheeja Rajasingh and Johnson Rajasingh 2. Hair Follicle-Associated Pluripotent (HAP) Stem Cells Robert M. Hoffman and Yasuyuki Amoh 3. Fluorescent Proteins as Sensors for Cellular Behavior in Mice Robert M. Hoffman 4. Arrestins: Introducing Signaling Bias Into Multifunctional Proteins Vsevolod V. Gurevich, Qiuyan Chen and Eugenia V. Gurevich 5. Analysis of Biased Agonism Frederick J. Ehlert 6. Effects of Estrogens on Central Nervous System Neurotransmission: Implications for Sex Differences in Mental Disorders Kristen N. Krolick, Qi Zhu and Haifei Shi

Each volume of Progress in Molecular Biology and Translational Science will be useful for scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. Volumes also are appropriate for new investigators to a field who wish to familiarize themselves with the latest work.

David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Co-Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.

• Comprises 15-20 chapters, which allows substantial coverage on a given topic
• Contains ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided in each chapter
• Provides a comprehensive guide to the latest information available on prions, viruses, bacteria, and eukaryotes