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Principles of Protein X-Ray Crystallography (3rd Ed., Softcover reprint of hardcover 3rd ed. 2007)

Langue : Anglais

Auteur :

Couverture de l’ouvrage Principles of Protein X-Ray Crystallography

X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.

Crystallizing a Protein.- X-ray Sources and Detectors.- Crystals.- Theory of X-ray Diffraction by a Crystal.- Average Reflection Intensity and Distribution of Structure Factor Data.- Special Forms of the Structure Factor.- The Solution of the Phase Problem by the Isomorphous Replacement Method.- Phase Improvement.- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Configuration.- Molecular Replacement.- Direct Methods.- Laue Diffraction.- Refinement of the Model Structure.- The Combination of Phase Information.- Checking for Gross Errors and Estimating the Accuracy of the Structural Model.- Practical Protein Crystallization.

Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands.

Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany.

Provides a comprehensive treatment of crystallographic fundamentals Extensively illustrated throughout Furnishes appropriate theoretical background for the understanding of protein structure determination at atomic resolution Written by a world-renowned crystallographer A vital tool in modern biochemistry, biophysics, molecular biology, and drug development

Ouvrage de 332 p.

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84,39 €

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Ouvrage de 332 p.

15.5x23.5 cm

Sous réserve de disponibilité chez l'éditeur.

Prix indicatif 116,04 €

Ajouter au panier