Plant-derived Pharmaceuticals Principles and Applications for Developing Countries

Describing recent developments in the engineering and generation of plants as production platforms for biopharmaceuticals, this book includes both vaccines and monoclonal antibodies. It has a particular emphasis on targeting diseases which predominate in less developed countries, encompassing the current state of technologies and describing expression systems and applications. This book also includes a variety of vaccine case studies, protecting against pervasive infectious diseases such as rabies, influenza and HIV.

1. Introduction

2. Protein Body-inducing Fusions for Recombinant Protein Production in Plants

3. Plant Cell Culture Expression Systems

4. Virus Expression Systems

5. Virus-like Particles

6. Glycol-engineering in Plants

7. Large Scale Production of Plant-made Therapeutic Protein

8. Patenting of Plant-made Vaccines and Access in the Developing World

9. Case Study 1: Plant-derived Vaccine against Cervical Cancer

10. Case study 2: Influenza Virus Vaccine

11. Case study 3: Plant-based GCD as Enzyme Replacement Therapy

12. Case study 4: Rabies

13. Case Study 5: HBV in Maize

14. Case Study 6: Plant-made HIV Vaccine

15. Case study 7: LT-B

16. Conclusion