Organic Stereochemistry Guiding Principles and Biomedicinal Relevance
Langue : Anglais
Auteur : TESTA Bernard
This book should become an indispensable asset on the bookshelves of
pharmaceutical laboratories in academia and in industry, as well as of
laboratories devoted to plant protection. Furthermore, for teachers in
this area it will not only be a useful compilation of the various
languages and definitions of organic stereochemistry, but also a welcome
source of examples for demonstrating to their students the intricate and
intriguing role stereochemistry plays in the chemistry of life. This
textbook presents the molecular scale of matter in the broad diversity and
richness of its three dimensions, giving due attention when relevant to
the temporal dimension in which molecules exist, act, and react. The focus
is on two significant fields of three-dimensional chemistry: a
presentation of the guiding principles in organic stereochemistry,
followed by a focus on the biochemical and medicinal relevance of this
discipline. The treatment of Guiding Principles gives priority to didactic
clarity and nomenclature issues, as detailed and illustrated in Parts 1 to
4: Symmetry Elements and Operations, Classification of Stereoisomers,
Stereoisomerism Resulting from One or Several Stereogenic Centers, Other
Stereogenic Elements: Axes of Chirality, Planes of Chirality, Helicity,
and (E,Z)-Diastereoisomerism, Isomerisms about Single Bonds and in Cyclic
Systems. This is followed by Parts 5 to 8 which focus on the biomedicinal
relevance of stereochemistry, with special reference to the biochemistry
and pharmacology of medicinal compounds. Here, examples and applications
are discussed and illustrated based on their relevance to a given specific
stereochemical aspect: Chirality in Molecular and Clinical Pharmacology,
The Conformational Factor in Molecular Pharmacology, The Concept of
Substrate Stereoselectivity in Biochemistry and Xenobiotic Metabolism,
Prostereoisomerism and the Concept of Product Stereoselectivity in
Xenobiotic Metabolism. Finally, the book contains a gift for broad-minded
readers with an interest in the historical roots of stereochemistry: Part
9: Molecular Chirality in Chemistry and Biology: Historical Milestones.
Date de parution : 04-2014
Disponible chez l'éditeur (délai d'approvisionnement : 12 jours).
Prix indicatif 90,46 €
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