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Nutraceuticals in Veterinary Medicine, 1st ed. 2019

Langue : Anglais

Coordonnateurs : Gupta Ramesh C., Srivastava Ajay, Lall Rajiv

Couverture de l’ouvrage Nutraceuticals in Veterinary Medicine

This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, probiotics, synbiotics, enzymes and antibacterial alternatives (Section-II), applications of nutraceuticals in prevention and treatment of various diseases such as arthritis, periodontitis, diabetes, cognitive dysfunctions, mastitis, wounds, immune disorders, and cancer (Section-III), utilization of nutraceuticals in specific animal species (Section-IV), safety and toxicity evaluation of nutraceuticals and functional foods (Section-V), recent trends in nutraceutical research and product development (Section-VI), as well as regulatory aspects for nutraceuticals (Section-VII). The future of nutraceuticals and functional foods in veterinary medicine seems bright, as novel nutraceuticals will emerge and new uses of old agents will be discovered.

International contributors to this book cover a variety of specialties in veterinary medicine, pharmacology, pharmacognosy, toxicology, chemistry, medicinal chemistry, biochemistry, physiology, nutrition, drug development, regulatory frameworks, and the nutraceutical industry. This is a highly informative and carefully presented book, providing scientific insight for academia, veterinarians, governmental and regulatory agencies with an interest in animal nutrition, complementary veterinary medicine, nutraceutical product development and research.


PRELIMINARY _03_2018


Introduction
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA; and  
Ajay Srivastava and Rajiv Lall, Vets Plus Inc, Menomonie, WI, USA
Email: rgupta@murraystate.edu; drajay@vets-plus.com; lallr@vets-plus.com

 
I. COMMON NUTRACEUTICALS 

1. Curcumin/Turmeric
Naresh Chand, National Institutes of Health, Bathesda, MD, USA
Email: nchand@mail.nih.gov
And
Sally Frautschy, University of California Los Angeles, Los Angeles, CA, USA
Email: sfrautschy@mednet.ucla.edu

2. Fenugreek
Dinesh Kumar, W. Ramdas Singh, Anu Rahal, and Jitendra K. Malik
Indian Veterinary Research Institute, Izatnagar, Bareilly, India
      Email: dineshks17@gmail.com

3. Ashwagandha
Vijay K. Bharti, Jitendra K. Malik, and Ramesh C. Gupta 
Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, India
Email: vijaykbharti@rediffmail.com

4. Shilajit
Shailesh K. Bhavsar*, Aswim M. Thaker, and Jitendra K. Malik
Anand Agricultural University, Anand, India
Email: skbhavsar@yahoo.com

5. Seabuckthorne and Apricot
Vijay K. Bharti
       Defense Institute of High Altitude Research (DIHAR), DRDO, Leh, India
       Email: vijaykbharti@rediffmail.com

6. Ginger
Shyam S. Sharma and K. Srinivasan, Dept. Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, Mohali, India
Email: sssharma@niper.ac.in

7. Neem extract
Jitendra K. Malik, Former Joint Director (Research), and Head of the Division    
 of Pharmacology and Toxicology, Indian Veterinary Research Institute,  
 Bareilly, Dehradun, Uttarakhand, India
 Email: jkmalik48@gmail.com

8. Omega fatty acids
Szabina A. Stice, Division of Biotechnology and GRAS Notice Review, FDA, College Park, MD, USA
E-mail: szabina.stice@fda.hhs.gov

9. L-Tryptophan and 5-HTP
Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA
Email: drajay@vets-plus.com

10. Berberine
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
Email: rgupta@murraystate.edu

11. Glucosinolates and organosulfur compounds
Karyn Bischoff, Cornell University, Ithaca, NY, USA
Email: klb72@cornell.edu

12. Nutraceutical values of red mold rice for anti-diabetic and anticlastogenic   properties
Jacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, Philippines
Email: jacobsanchezph1@gmail.edu

13. Medium Chain Triglycerides
Yet to be assigned
 Email: 

14. Colostrum and Immunoglobulins 
 Dan Duberdieu, Vets Plus Inc, Menomonie, WI, USA
 Email: dand@vets-plus.com

15. Herbal Marijuana/Cannabis sativa
Joshua A. Hartsel, Delta-9 Technologies, LLC, Lake Forest, CA, USA
Email: jhartsel@gmail.edu
      
16. Juniper
 Rajinder Raina, Pawan K. Verma, Jitendra K. Malik, and Ramesh C. Gupta 
 Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu,       
 Jammu, India
 Email:  drrajinderraina@ymail.com

17. Natural preservatives and food additives
Ajay Srivastava and Tapan Gor, Vets Plus Inc, Menomonie, WI, USA
Email: drajay@vets-plus.com

18. Antioxidants in animal health 
Yogendra K. Gupta, All India Institute of Medical sciences. New Delhi, India
Email: ykgykg@gmail.com  or ykg@hotmail.com 
  
19. Polyphenols and flavonoids
       Satish K. Garg, Soumen Choudhury and Amit Shukla
       U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan    
        Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, India    
       Email: profsatish@gmail.com

        
II. PREBIOTICS, PROBIOTICS, SYNBIOTICS, AND ANTIMICROBIALS

20. Prebiotics and probiotics in feed and animal health
      Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain
       Email: anadon@vet.ucm.es

21. Synbiotics in animals health
      Jitendra K. Malik and Ramesh C. Gupta
       Former Joint Director (Research), and Head of the Division of     
       Pharmacology and Toxicology, Indian Veterinary Research Institute, Bareilly, 
       Dehradun, Uttarakhand, India
       Email: jkmalik48@gmail.com

22. Enzymes in feed and animal health
       Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain
       Email: anadon@vet.ucm.es

23. Optimization of mineral supplements for maximized animal productivity
Jeffery O. Hall, Utah State University, Logan, UT, USA
Email: jeffery.hall@usu.edu

24. Nutraceuticals used as antibacterial alternatives in animal health
      Arturo Anadon, Universidad Complutense de Madrid, Madrid, Spain
       Email: anadon@vet.ucm.es

25. Feed additives in animal health
Prafull Kumar and M.J. Saxena, Ayurvet, Ghaziabad, UP, India
Email:  pverma@ayurvet.com; mjsaxena@ayurvet.com



III. NUTRACEUTICALS IN ORGAN/SYSTEM DISORDERS

26. Nutraceuticals in arthritis
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
E-mail: rgupta@murraystate.edu

27. Nutraceuticals in oral health and periodontal diseases
 Yet to be assigned
        Email: 

28. Nutraceuticals in gastrointestinal conditions
Jamil Talukder, Vets Plus Inc, Menomonie, WI, USA
Email: jamilt@vets-plus.com

29. Nutraceuticals in hepatic and pancreatic diseases
Sharon Gwaltney-Brant, University of Illinois, Urbana-Champaign, IL, USA
Email: sharon.brant@mchsi.com

30. Nutraceuticals in genitourinary diseases
Robert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USA
Email: r.coppock@toxicologist.ca

31. Nutraceuticals in cardiovascular diseases
Csaba Zoltani, Emeritus US Army Research Lab, Aberdeen Proving Ground, MD, USA
Email: c.zoltani@gmail.com

32. Nutraceuticals in respiratory diseases
Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA
Email: drajay@vets-plus.com

33. Nutraceuticals in reproductive disorders
Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA
Email: mwoldem@uga.edu

34. Nutraceuticals in dermatological disorders
Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA
Email: mwoldem@uga.edu

35. Nutraceuticals in mastitis
 Robert W. Coppock, Toxicologist and Assoc Ltd, Vegreville, AB, Canada, USA
 Email: r.coppock@toxicologist.ca

36. Nutraceuticals in immune disorders
Moges Woldemeskel, College of Veterinary Medicine, University of Georgia, GA, USA
Email: mwoldem@uga.edu

37. Nutraceuticals for wound healing
Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA
Email: drajay@vets-plus.com

38. Nutraceuticals for calming and stress
 Yet to be assigned
 Email:

39. Nutraceuticals for cognitive dysfunction
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
Email: rgupta@murraystate.edu

40. Nutraceuticals for antiaging
Yet to be assigned
 Email:

41. Nutraceuticals in cancer prevention and cure
 Subhash C. Gupta, Banaras Hindu University, Banaras, UP, India
Email: subhashg167@gmail.com

42. Nutraceuticals alone or in combination with chemotherapeutic agents for prevention and treatment of cancer
M. Waheed Roomi, Dr Rath Research Institute, Santa Clara, CA, USA
Email: w.roomi@drrath.com

43. Nutraceuticals in obesity and metabolic disorders
Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia
Email: rhian.Cope@health.gov.au

44. Nutraceuticals for ticks, fleas and other ectoparasites
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
Email: rgupta@murraystate.edu

45. Nutraceuticals in hunting, sporting and performance enhancing activities
Yet to be assigned
 Email:  
 

IV. NUTRACEUTICALS IN SPECIFIC ANIMAL SPECIES

46. Nutraceuticals in cattle health and diseases
Ayhan Filazi and Begum Yurdakok Dikmen, Ankara University, Ankara, Turkey
Email: afilazi@gmail.com

47. Nutraceuticals in equine health and diseases
Yet to be assigned
 Email:

48. Nutraceuticals in camelids
 Tarun K. Gahlot, Bikaner Veterinary Science University, 
  Bikaner, India
 Email: tkcamelvet@yahoo.com

49. Nutraceuticals in poultry health and diseases
 Begum Yurdakok Dikmen and Ayhan Filazi, Ankara University, Ankara,     
 Turkey
Email: byurdakok@yahoo.com


V. SAFETY AND TOXICITY EVALUATION OF FUNCTIONAL FOODS AND NUTRACEUTICALS

50. Safety and toxicity evaluation of nutraceuticals in animal models
Nikolay Goncharov, Russian Academy of Sciences, Saint Petersburg, Russia
Email: ngoncharov@gmail.com

51. Safety and toxicity evaluation of nutraceuticals using alternative in vitro      
 models 
 Subhash C. Gupta, Banaras Hindu University, Banaras, UP, India
Email: subhashg167@gmail.com

52. Safety of pet food, functional food, and nutraceuticals
Sandra James-Yi, Now Health Group, Inc., Bloomingdale, IL, USA
Email: Sandra.james-yi@nowfoods.com

53. Hydrocolloids: safety and toxicity considerations
Larry J. Thompson, Nestle Purina PetCare, St. Louis, MO, USA
Email: larry.thompson@rdmo.nestle.com

54. Biomarkers for selected foods  and nutraceuticals
Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
Email: rgupta@murraystate.edu

55. Toxic interaction of nutraceuticals with food and pharmaceuticals
 Ramesh C. Gupta, Murray State University, Hopkinsville, KY, USA
 Email: rgupta@murraystate.edu
 Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia
 Email: rhian.Cope@health.gov.au


VI. NUTRACEUTICAL PRODUCT DEVELOPMENT

56. Nutraceuticals palatability process and study
Ajay Srivastava, Vets Plus Inc, Menomonie, WI, USA
 Email: drajay@vets-plus.com

57. Steps to conduct nutraceutical clinical efficacy trials 
Isabelle Mougeot, CanCog technologies Inc, Toronto, ON, Canada
Email: isabellem@cancog.com

58. Nutraceuticals stability study
Dan Duberdieu, Vets Plus Inc, Menomonie, WI, USA
Email: dand@vets-plus.com


VII. NEWER TRENDS IN NUTRACEUTICAL RESEARCH

59. Nanosupplements  and animal health
Francesca Caloni, Universita degli Studi di Milano, Milan, Italy
Email: francesca.caloni@unimi.it

60. Fabrication and use of nanoparticles in delivery of dietary ingredients and nutraceuticals to biological system
Gianfranco Risuleo, Sapienza University of Rome, Rome, Italy
Email: gianfranco.risuleo@gmail.com

61. Proteomics in evaluation of nutraceuticals and functional food
Christina R. Wilson, Dept. Comparative Pathology, Purdue University,          West Lafayette, IN, USA
Email: wilsonc@purdue.edu

62. Bioavailability of nutraceuticals
Gianfranco Risuleo, Sapienza University of Rome, Rome, Italy
Email: gianfranco.risuleo@gmail.com



VIII. REGULATORY ASPECT OF NUTRACEUTICALS

63. Role of AAFCO in functional food and nutraceutical regulations
Anita Sinha and Bill Bookout , Vets Plus Inc, Menomonie, WI, USA
Email: anitas@vets-plus.com and b.bookout@nasc.cc  

64. Role of NASC in functional food and nutraceutical regulations
Bill Bookout and Anita Sinha, Vets Plus Inc, Menomonie, WI, USA
Email: b.bookout@nasc.cc  and  anitas@vets-plus.com

65. Regulatory guidelines for nutraceuticals in the EU
Doriana Tedesco, Milano University, Milano, Italy
Email: Doriana.tedesco@unimi.it

66. US FDA’s perspective in regulation of veterinary nutraceuticals 
Daljit Vudathala, University of Pennsylvania, Kennet Square, PA, USA
Email: vudathal@vet.upenn.edu

67. Regulatory guidelines for nutraceuticals in Australia and New Zealand
 Rhian B. Cope, Health Product Regulation Group, Woden ACT, Australia
 Email: rhian.Cope@health.gov.au

68. Regulatory guidelines for nutraceuticals and food supplements in India
 Pawan K. Gupta, Bareilly, India
 Email: drpkg_brly@yahoo.co.in

69. Regulatory guidelines for nutraceuticals in China
Yet to be assigned
 Email:

70. Regulatory guidelines for nutraceuticals and food supplements in Turkey
 Begum Yurdakok Dikmen, and Ayhan Filazi, Ankara University, Ankara, 
 Turkey
 Email: byurdakok@yahoo.com

71. Uses and regulatory guidelines of nutraceuticals in Philippines
Jacob A. C. Sanchez, Pampanga State Agricultural University, Pampanga, Philippines
Email: jacobsanchezph1@gmail.com

72. Regulatory guidelines for nutraceuticals in South America
Yet to be assigned
 Email:

73. Regulatory guidelines for nutraceuticals in South Africa
Vinny Naidoo, University of Pretoria, Onderstepoort, Republic of South 
Africa
Email: vinny.naidoo@up.ac.za

Dr. Ramesh C. Gupta serves as Professor and Head of the Toxicology Department at the Murray State University Breathitt Veterinary Center. He earned his DVM, MVSc, and PhD in India, and carried out his postdoctoral training at Michigan State University and Vanderbilt University, US. His research has addressed experimental brain research in relation to pesticide toxicity and neurological diseases; he has further been heavily engaged in veterinary nutraceuticals research. Dr. Gupta has held worldwide presentations and served on the panels of NIH, CDC, NIOSH, and NAS. He has published >400 publications, including 7 major books. In 2006, he received the Murray State University Distinguished Researcher Award; and in 2014, the Outstanding Research Award. He is a Diplomate of the American Board of Toxicology, and Fellow of the American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences. Currently, he holds active membership in more than a dozen academic societies.

Dr. Ajay Srivastava is Chief Scientific Officer at Vets Plus Inc., and serves as an adjunct Faculty member at University of Wisconsin-Stout, Menomonie, US. He is specialized in preclinical and clinical product development and nutraceutical research. After receiving his BS in Biological Sciences, Dr. Srivastava earned his DVM from the School of Veterinary Medicine at GB Pant University of Agriculture and Technology, India, before pursuing his MS in Pharmacology. He completed his PhD in Neuropharmacology from All India Institute of Medical Sciences, New Delhi. After his post-doctoral training in preclinical drug development in neurological disorders, Dr. Srivastava became Senior Research Scientist of the Anticonvulsant Drug Development Program at the University of Utah, where he developed a novel animal model of pharmacoresistant epilepsy to screen potential antiepileptic drugs. He is one of the pioneer researchers who discovered t

Covers veterinary nutraceuticals most comprehensively from ingredients to final products

Offers standalone chapters on all important aspects and provides scientific rationale for nutraceuticals’ use

User-friendly text enriched with most recent literature and references

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