Non-Canonical Autophagy Mechanisms and Pathophysiological Implications
Coordonnateurs : Petroni Giulia, Galluzzi Lorenzo
1. Introduction: canonical vs non-canonical autophagy 2. Overview of Canonical Autophagy 3. Overview of Non-Canonical Autophagy 4. LC3-associated phagocytosis (LAP) 5. Autophagy-dependent cell death (ADCD) 6. Therapeutic targeting of non-conventional autophagy: potential benefits and pitfalls
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
- Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy
- Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes
- Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Date de parution : 04-2021
Ouvrage de 182 p.
15x22.8 cm
Thème de Non-Canonical Autophagy :
Mots-clés :
Acetyl CoA; AMPK; ATG; ATG5BECN1Cancer; Autophagic cell death (ACD)Autophagic flux; Autophagosome-lysosome fusion; Autophagosome; Autophagy; Autophagy-dependent cell death (ADCD)Lysosomal-dependent cell death; Autophagy-related proteins; Beclin-1EP300Fatty acids; Beclin-1Macroautophagy; Cell death; Endocytosis; Exocytosis; Inflammation; LAP; LC3-associated phagocytosis; Lysosomes; Metabolism; MHC class I internalization; MHC molecules; mTORC1Neurodegeneration; mTORC1Sirtuins; Pathogen; Pathology; Rubicon; Self-eating; T cells; Ubiquitin-like conjugation systems; UKL complex; ULK1VPS34