Neurobiology of TRP Channels Frontiers in Neuroscience Series

During the last two decades, there has been an explosion of research pertaining to the molecular mechanisms that allow for organisms to detect different stimuli that is an essential feature for their survival. Among these mechanisms, living beings need to be able to respond to different temperatures as well as chemical and physical stimuli.

Thermally activated ion channels were proposed to be present in sensory neurons in the 1980s, but it was not until 1997 that a heat- and capsaicin- activated ion channel, TRPV1, was cloned and its function described in detail. This groundbreaking discovery led to the identification and characterization of several more proteins of the family of Transient Receptor Potential (TRP) ion channels.

Intensive research has provided us with the atomic structures of some of these proteins, as well as understanding of their physiological roles, both in normal and pathological conditions. With chapters contributed by renowned experts in the field, Neurobiology of TRP Channels contains a state- of- the- art overview of our knowledge of TRP channels, ranging from structure to their functions in organismal physiology.

Features:

? Contains chapters on the roles of several TRP ion channels with a diversity of physiological functions, providing a complete picture of the widespread importance of these proteins.

? Presents an overview of the structure of TRP channels, including the roles of these proteins in different physiological processes.

? Discusses the roles of TRP channels in pathophysiological processes, further highlighting their importance.

? Features several full color illustrations to allow the reader better comprehension of TRP channels.

A volume in the Frontiers in Neuroscience series

TRP channels in Vision. Sensory Mechano Transduction and Thermotransduction in Worms. Osmomechanical-Sensitive TRP channels in Vertebrates. A critical Role for TRP channels in the Skin. Olfactory Transduction and its Coupling to TRP channels: Interactions with G proteins. The Neurobiology of Taste and TRP channels. The Molecular Basis of Thermosensation. TRP channels and Pain. The Role of TRP channels in the Gut. The Cardiovascular System and TRP channels. TRP channels in Renal Physiology. Fertility and TRP channels. TRP channels and the Endocrine System. Airway Inflammation is Linked to TRP channels. How Thermo-TRP's Regulate Longevity. TRP channels in the Brain: What Are They There For?

Tamara Rosenbaum obtained her B.Sc in Biology and then her Doctorate Sciences from the National Autonomous University of Mexico (UNAM). After her postdoctoral training in the laboratory of Dr. Sharona Gordon at the University of Washington, she established her own lab in the Instituto de Fisiología Celular at UNAM in late 2004. Since then she has worked on the structure-function relationships of the TRPV1 channel.