Lavoisier S.A.S.
14 rue de Provigny
94236 Cachan cedex
FRANCE

Heures d'ouverture 08h30-12h30/13h30-17h30
Tél.: +33 (0)1 47 40 67 00
Fax: +33 (0)1 47 40 67 02


Url canonique : www.lavoisier.fr/livre/sciences-de-la-vie/molecular-et-biochemical-toxicology-4th-ed/smart/descriptif_1340956
Url courte ou permalien : www.lavoisier.fr/livre/notice.asp?ouvrage=1340956

Molecular & biochemical toxicology (4th Ed.)

Langue : Anglais

Auteur :

Couverture de l’ouvrage Molecular & biochemical toxicology
Introductory book providing in-depth information on the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse responses. Toxicologic issues are covered from both an organ-based approach along with the basic principles of toxicology and methodology. New edition adds timely and thorough coverage of molecular toxicology, like proteomics, toxicogenomics, metabolomics, bioinformatics, and pharmaco(toxico)genetics. Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts.
Preface.

Contributors.

1. Molecular and Biochemical Toxicology: Definition and Scope (Ernest Hodgson and Robert C. Smart).

1.1 Introduction.

1.2 Toxicology.

1.3 Biochemical Toxicology.

1.4 Cellular Toxicology.

1.5 Molecular Toxicology.

1.6 Proteomics, Metabolomics.

1.7 Conclusions.

Suggested Reading.

2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes (Robert C. Smart).

2.1 Applicability of Molecular Techniques to Toxicology.

2.2 Overview of the Genetic Code and Flow of Genetic Information.

2.3 Molecular Cloning.

2.4 Southern and Northern Blot Analyses.

2.5 Polymerase Chain Reaction (PCR).

2.6 Some Methods to Evaluate Gene Expression and Regulation.

2.7 Methods to Evaluate Gene Function.

3. Toxicogenomics (Marjorie F. Oleksiak).

3.1 Introduction.

3.2 A Primer of Genomics.

3.3 Tools and Approaches.

3.4 Genomes.

3.5 Functional Genomics.

3.6 Conclusions.

4. Proteomics (B. Alex Merrick).

4.1 Introduction to Proteomics.

4.2 Properties of Proteins.

4.3 Fields of Proteomic Research.

4.4 Mass Spectrometers and Protein Identification.

4.5 Proteomic Platforms.

4.6 Proteomes and Subproteomes: Expectations and Reality.

4.7 Summary.

5. Metabolomics (Nigel Deighton).

5.1 Introduction.

5.2 Methods.

5.3 Diagnostics and Functional Genomics.

5.4 Metabolomics and Toxicology.

6. Bioinformatics (Eric A. Stone and Dahlia M. Nielsen).

6.1 Introduction.

6.2 Obtaining the Genbank Record of a Known Gene.

6.3 Sequence Comparison.

6.4 Database Searching With BLAST.

6.5 Extensions to Multiple Sequences.

6.6 Genetic Mapping.

6.7 Conclusion.

7 Immunochemical Techniques in Toxicology (Gerald A. LeBlanc).

7.1 Introduction.

7.2 Definitions.

7.3 Immunogens and Antigens.

7.4 Polyclonal Antibodies.

7.5 Monoclonal Antibodies.

7.6 Immunoassays.

7.7 Conclusions.

8. Cellular Techniques (Sharon A. Meyer).

8.1 Introduction.

8.2 Cellular Studies in Intact Tissue.

8.3 Studies with Dispersed, Isolated Cells.

8.4 Monolayer Cell Culture.

8.5 Observation of Cultured Cells.

8.6 Indicators of Toxicity.

8.7 Artifacts and Confounders.

8.8 Replacement of Animal Testing with Cell Culture Models.

8.9 Conclusions.

9. Structure, Mechanism and Regulation of Cytochromes P450 (Darryl C. Zeldin and John M. Seubert).

9.1 Introduction.

9.2 Complexity of the Cytochrome P450 Gene Superfamily.

9.3 Cytochrome P450 Structure.

9.4 Mechanisms of P450 Catalysis.

9.5 Cytochrome P450 Regulation.

9.6 Transgenic Animal Models.

9.7 Reactive Oxygen Species.

9.8 Posttranslation Modification of P450s.

9.9 Summary.

10. Phase I Metabolism of Toxicants and Metabolic Interactions (Ernest Hodgson, Parikshit C. Das, Taehyeon M. Cho and Randy L. Rose).

10.1 Introduction.

10.2 Microsomal Monooxygenations: General Background.

10.3 Nonmicrosomal Oxidations.

10.4 Cooxidation by Prostaglandin Synthetase.

10.5 Reduction Reactions.

10.6...

Graduate-level toxicology courses

Date de parution :

Ouvrage de 958 p.

Sous réserve de disponibilité chez l'éditeur.

Prix indicatif 114,03 €

Ajouter au panier

Thèmes de Molecular & biochemical toxicology :

Ces ouvrages sont susceptibles de vous intéresser