Molecular, Clinical and Environmental Toxicology, 2009 Volume 1: Molecular Toxicology Experientia Supplementum Series, Vol. 99

Langue : Anglais

Coordonnateur : Luch Andreas

Couverture de l’ouvrage Molecular, Clinical and Environmental Toxicology

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Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

- AN Hayes SG Gilbert: Historical milestones and discoveries that shaped the toxicology sciences - D Kim and LA Nylander-French: PBTK models in exposure assessment - W Dekant: The role of biotransformation and bioactivation in toxicity - DH Phillips and VM Arlt: Genotoxicity: damage to DNA and its consequences - U Camenisch and H Naegeli: Role of DNA repair in the protection against genotoxic stress - A Luch: On the impact of the molecule structure in chemical carcinogenesis - J Högberg, I Silins and U Stenius: Chemical induced alterations in p53 signaling - R Sánchez-Olea, MR Calera and A Degterev: Molecular pathways involved in cell death after chemically induced DNA damage - C Ma, JL Marlowe and A Puga: The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways - JL Marlowe, SS Teo, SD Chibout, F Pognan and J Moggs: Mapping the epigenome – impact for toxicology - J Rüegg, P Penttinen-Damdimopoulou, S Mäkelä, I Pongratz and JÅ Gustafsson: Receptors mediating toxicity and their involvement in endocrine disruption - T Zhou, J Chou, PB Watkins and WK Kaufmann: Toxicogenomics: transcription profiling for toxicology assessment - BA Merrick and FA Witzmann: The role of toxicoproteomics in assessing organ specific toxicity - WGEJ Schoonen, WMA Westerink and GJ Horbach: High-throughput screening for analysis of in vitro toxicity

Presents milestones and recent achievements of toxicology

Explains mechanisms of toxicity at the molecular level

Discusses toxicogenomics and individual variability