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Molecular biology of the gene (7th Ed.)

Langue : Anglais

Auteurs :

Couverture de l’ouvrage Molecular biology of the gene
Now completely up-to-date with the latest research advances, the Seventh Edition of James D. Watson’s classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology.

I.  HISTORY

1. Mendelian View of the World

2. Nucleic Acids Convey Genetic Information

 

II. STRUCTURE AND STUDY OF MACROMOLECULES

3. Weak and strong chemical bonds.

4. The Structure of DNA

5. The Structure of RNA

6. The Structure of Proteins and Protein: Nucleic Acid Interactions

7. Techniques of Molecular Biology

 

III. MAINTENANCE OF THE GENOME

8. Genome Structure, Chromatin and the Nucleosome

9. The Replication of DNA

10. The Mutability and Repair of DNA

11. Homologous Recombination at the Molecular Level

12. Site Specific Recombination and Transposition of DNA

 

IV.  EXPRESSION OF THE GENOME

13. Mechanisms of Transcription

14. RNA Splicing

15.  Translation

16.  The Genetic Code

17.  Origins and early evolution of life

 

V.  REGULATION

18. Transcriptional Regulation in Prokaryotes

19. Transcriptional Regulation in Eukaryotes

20. Regulatory RNAs

21. Gene Regulation in Development and Evolution

22. Systems Biology

 

APPENDIX:

Model Organisms

James D. Watson is Chancellor Emeritus at Cold Spring Harbor Laboratory, where he was previously its Director from 1968 to 1993, President from 1994 to 2003, and Chancellor from 2003 to 2007. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in 1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth, fifth and sixth editions. These were published in 1965, 1970, 1976, 1987, 2003, and 2007, respectively. He is also a co-author of two other textbooks: Molecular Biology of the Cell and Recombinant DNA, as well as author of the celebrated 1968 memoir, The Double Helix, which in 2012 was listed by the Library Of Congress as one of the 88 books that shaped America.
________________________________________
Tania A. Baker is the Head of the Department and Whitehead Professor of Biology at the Massachusetts Institute of Technology, and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdocto
  • Balanced coverage of prokaryotic and eukaryotic systems is included.
  • To support the concise narrative, additional material can be found in essay boxes that are labeled in four categories:
    • Key or Classic Experiments highlight influential experimental strategies that show students how we know what we know.
    • Techniques include recent methods from the fields of bioinformatics and genomics.
    • Advanced Concepts provide further discussions of key theories and principles.
    • Medical Connections highlight how understanding basic mechanisms sheds light on—and may lead to treatment of—medical conditions and human diseases.

Date de parution :

Ouvrage de 872 p.

22x28 cm

Disponible chez l'éditeur (délai d'approvisionnement : 14 jours).

Prix indicatif 215,18 €

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