Molecular Biology of Metal Homeostasis and Detoxification, 2006 From Microbes to Man Topics in Current Genetics Series, Vol. 14

One of the challenges faced by every cell as well as by whole organisms is to maintain appropriate concentrations of essential nutrient metals while excluding nonessential toxic metals. Toward that end, all organisms have developed mechanisms for metal homeostasis and detoxification to maintain metal levels within physiological limits. This book brings together current knowledge of the molecular basis of metal homeostasis and detoxification in various eukaryotic model systems, including yeasts, plants, and mammals. It focuses on the cellular systems controlling metal transport, intracellular distribution, and immobilization as well as on systems regulating metal-dependent transcription. In addition to environmental aspects (including phytoremediation), the book treats the pathophysiology of metal deficiency and overload in relation to disease.

A milestone in metal biology

Addresses both essential and toxic metals and looks at their effects in a range of different organisms

A must have for postgraduates and researchers alike

Includes supplementary material: sn.pub/extras