Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more.

1. ?ardiotonic steroids, Na+, K+ pump and vascular fibrosis Alexei Bagrov 2. Control of lung myofibroblast transformation by monovalent ion transporters Sergei Orlov 3. Purinergic signaling in the lung: a search for membrane mechanisms of ATP release Ryszard Grygorczyk 4. Structural model of a2-subunit N-terminus and its binding interface for Arf-GEF cytohesin-2: Implication for regulation of V-ATPase function and rational drug design Vladimir Marshansky 5. Ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients: Physiological and pathophysiological implications Elizaveta Klimanova 6. The Na, K-ATPase alpha2 isoform in cardiovascular pathologies Vladimir Matchkov 7. Critical Role of Cell Swelling and Volume-Sensitive Ion Channels in Stroke Pathology Alexander A. Mongin 8. Structure-function relationships in the renal NaCl cotransporter Gerardo Gamba 9. Roles of volume-activated anion channels in necrotic, apoptotic and ischemic cell death Yasunobo Okada 10. Molecular mechanism for the regulation of blood pressure by potassium Maria Castañeda-Bueno 11. Hormonal regulation of Na+,K+-ATPase from the evolutionary perspective Alexander Chibalin 12. Ion channels and carriers in diabetic kidney disease Alexander Staruschenko

University professors, researchers, physicians, and students.

• Provides the authority and expertise of leading contributors from an international board of authors
• Presents the latest release in the Current Topics in Membranes series
• Includes the latest information on membrane ion transporters