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Kratom and Other Mitragynines The Chemistry and Pharmacology of Opioids from a Non-Opium Source

Langue : Anglais

Coordonnateur : Raffa Robert B.

Couverture de l’ouvrage Kratom and Other Mitragynines

Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature’s only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds—those derived from the plant Mitragyna speciosa. This plant, known as Kratom in Thailand or Biak-Biak in Malaysia, has long been used locally as treatment for pain, fever reduction, diarrhea, and even depression. Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source presents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."

Why Do Plants Contain Biologically Active Compounds?

Short Overview of Mitragynines

Psychopharmacological Indole Alkaloids from Terrestrial Plants

Salvinorin A: Example of a Non-Alkaloidal Bioactive Opioid from a Plant Source

Mitragyna speciosa (Korth.) Havil

Phytochemistry of Mitragyna speciosa

Chemistry of Mitragynines: A Brief Introduction

Chemistry of Mitragyna Compounds

Medicinal Chemistry Based on Mitragynine

Chemical Structures of Opioids

The Detection of Mitragynine and Its Analogs

The ADME of Mitragynine and Analogs

Analgesic Effects of Mitragynine and Analogs

Non-Analgesic CNS Effects

Other Opioid-Associated Endpoints

The Kratom Experience From Firsthand Reports

The Toxicology of Indole Alkaloids

Opioid-Induced Adverse Effects and Toxicity

Toxicology of Mitragynine and Analogs

The Use of Animal Models to Measure Tolerance, Dependence, and Abuse Potential

Kratom: The Epidemiology, Use and Abuse, Addiction Potential, and Legal Status

Pharmacologists, medicinal chemists, pharmacists, drug abuse treatment specialists, psychologists, psychiatrists, pain management practitioners, treatment centers, regulatory agency personnel, health economists, HMOs, and pharmaceutical companies involved in pain products.

Date de parution :

Ouvrage de 366 p.

15.2x22.9 cm

Disponible chez l'éditeur (délai d'approvisionnement : 13 jours).

Prix indicatif 122,83 €

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