Kratom and Other Mitragynines The Chemistry and Pharmacology of Opioids from a Non-Opium Source
Coordonnateur : Raffa Robert B.
Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature’s only source of opioids. But it now appears that biological diversity has evolved an alternative source of opioid compounds—those derived from the plant Mitragyna speciosa. This plant, known as Kratom in Thailand or Biak-Biak in Malaysia, has long been used locally as treatment for pain, fever reduction, diarrhea, and even depression. Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opioids from a Non-Opium Source presents an introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogs. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addiction potential are also discussed. As the first extensive text on the basic science and clinical use of Kratom, the book provides readers with a concise yet comprehensive introduction to nature’s "other opioid."
Why Do Plants Contain Biologically Active Compounds?
Short Overview of Mitragynines
Psychopharmacological Indole Alkaloids from Terrestrial Plants
Salvinorin A: Example of a Non-Alkaloidal Bioactive Opioid from a Plant Source
Mitragyna speciosa (Korth.) Havil
Phytochemistry of Mitragyna speciosa
Chemistry of Mitragynines: A Brief Introduction
Chemistry of Mitragyna Compounds
Medicinal Chemistry Based on Mitragynine
Chemical Structures of Opioids
The Detection of Mitragynine and Its Analogs
The ADME of Mitragynine and Analogs
Analgesic Effects of Mitragynine and Analogs
Non-Analgesic CNS Effects
Other Opioid-Associated Endpoints
The Kratom Experience From Firsthand Reports
The Toxicology of Indole Alkaloids
Opioid-Induced Adverse Effects and Toxicity
Toxicology of Mitragynine and Analogs
The Use of Animal Models to Measure Tolerance, Dependence, and Abuse Potential
Kratom: The Epidemiology, Use and Abuse, Addiction Potential, and Legal Status
Date de parution : 10-2014
Ouvrage de 366 p.
Disponible chez l'éditeur (délai d'approvisionnement : 13 jours).
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