Ion Channels and Calcium Signaling in the Microcirculation

Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more.

Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.

1. Introduction to ion channels and calcium signaling in the microcirculation William F. Jackson 2. Ion channels and the regulation of myogenic tone in peripheral arterioles William F. Jackson 3. Endothelial inwardly-rectifying K⁺ channels as a key component of shear stress-induced mechanotransduction Ibra S. Fancher and Irena Levitan 4. Endothelial TRPV4 channels and vasodilator reactivity Yen-Lin Chen and Swapnil K. Sonkusare 5. Regulation of vascular tone by transient receptor potential ankyrin 1 channels Pratish Thakore, Sher Ali and Scott Earley 6. Regulation of ion channels in the microcirculation by mineralocorticoid receptor activation Laura Chambers and Anne M. Dorrance 7. Ion channels and myogenic activity in retinal arterioles Peter Barabas, Josy Augustine, José A. Fernández, J. Graham McGeown, Mary K. McGahon and Tim M. Curtis 8. K_IR channels in the microvasculature: Regulatory properties and the lipid-hemodynamic environment Maria Sancho and Donald G. Welsh 9. Ion channels in capillary endothelium Daniela C. G. Garcia and Thomas A. Longden 10. Excitability and contractility in arterioles and venules from the urinary bladder Nathan R. Tykocki and Frederick C. Monson 11. Intrinsic regulation of microvascular tone by myoendothelial feedback circuits Hamish A.L. Lemmey, Christopher J. Garland and Kim A. Dora

• Presents the latest volume in the Current Topics in Membranes series, with a novel focus on smooth muscle and endothelial cells in the peripheral microcirculation
• Provides authoritative contributions from an international team of leading experts actively studying the microcirculation
• Includes a unique focus on regional heterogeneity in ion channel expression and function in the peripheral microcirculation