Ibuprofen: Pharmacology, Therapeutics and Side Effects, 2012 Pharmacology, therapeutics and side effects

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.

Introduction.- Biodisposition in relation to actions.- Mechanisms of inflammation and sites of action of NSAIDs.- Clinical efficacy.- Drug derivatives and formulations.- General safety profile.- Gastro-intestinal toxicity.- Cardiovascular safety.- Renal toxicity.- Hepatic toxicity.- Other adverse reactions.- Global assessment of adverse reactions & human toxicology.- Overall assessment.

Emphasis on the scientific evidence for safety of ibuprofen especially at OTC dosage

Critical reviews of recent clinical trails

Written in a general style, easy to understand for a broader readership

The author is an internationally recognized expert in the field of inflammation and pharmacology of anti-rheumatic and anti-inflammatory drugs

Includes supplementary material: sn.pub/extras

Includes supplementary material: sn.pub/extras