Human Microbiota in Health and Disease From Pathogenesis to Therapy

Human Gut Microbiota in Health and Disease: From Pathogenesis to Therapy is a comprehensive discussion of all the aspects associated with gut microbiota early colonization, its development and maintenance, and its symbiotic relationship with the host to promote health.

Chapters illustrate the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation of glucose, lipid and energy homeostasis and immune response, while mediating inflammatory processes involved in the etiology of many chronic disease conditions. Details are provided on the primary etiological factors of chronic disease, the effects of gut dysbiosis and its associated disease conditions, while providing an overview of therapeutic strategies involving dietary fiber and prebiotics, fecal microbiota transplantation therapy and probiotics. Throughout the chapters, a comprehensive review of peer-reviewed animal and human studies is provided as evidence related to the history of human exposure, safety, tolerance, toxicity, nomenclature, and clinical efficacy of utilizing prebiotic fructans, s, as well as probiotic intervention, and dietary modification in the prevention and intervention of chronic disease conditions.

With common use today of pharmaceutical medicine in treating symptoms, and frequent overuse of antibiotics in chronic disease within mainstream medical practice, understanding the etiological mechanisms of dysbiosis-induced chronic disease, and natural approaches that offer prevention and potential cures for these diseases is of vital importance to overall human health.

1. Gut Microbiota, Early Colonization and Factors in its Development that Influence Health2. Microbiota Short Chain Fatty Acid (Scfa) Production and Host Metabolism 3. Gut Microbiota Influence Bile Acid Metabolism to Effect Lipid and Glucose Metabolism, Energy Homeostasis and Inflammation4. Role of Gut Microbiota in Immune Homeostasis5. Direct Physiological Effects on Local Gi Function and Indirect Systemic Effects of Prebiotic Fructan Treatment and Its Role in Disease Prevention and Therapy6. Immune and Physiological Impairment and Intestinal-Based Diseases Associated with Gut Dysbiosis: Natural Therapeutic Use of Pre- and Probiotics7. Overview of Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Prebiotics8. Prebiotic Fructans9. Dysbiosis of the Microbiota: Therapeutic Strategies Utilizing Dietary Modification, Pro- and Prebiotics and Fecal Microbial Transplant Therapies in Promoting Normal Balance and Local Gi Functions 10. Oral Dysbiosis and Periodontal Disease: Impaired Systemic Physiology and Metabolic Diseases, Effects of Various Therapeutic Strategies11. Intestinal Dysbiosis in Obesity, Metabolic Syndrome and Related Metabolic Diseases: Therapeutic Strategies Utilizing Pro- and Prebiotics12. Gut Microbiota in Brain Development and Disorders of the CNS: Therapeutic Strategies Involving Dietary Modification and Pro- and Prebiotic Intervention13. The Gut-Brain-Skin Axis and Role of Intestinal Dysbiosis in Acne Vulgaris: Therapeutic Effects of Pro- and Prebiotic Use14. Microbiota: Role of Dysbiosis in Urogential Infections

Biomedical researchers who focus on understanding the complex mechanisms and metabolic signalling pathways related to how the gut microbiota maintain proper regulation; gastroenterologists and professionals of the functional foods industry

• Details the complex relationship between human microbiota in the gut, oral cavity, urogenital tract and skin as well as their colonization, development and impact of factors that influence the relationship
• Illustrates the mechanisms associated with dysbiosis-associated inflammation and its role in the onset and progression in chronic disease
• Provides the primary mechanisms and comprehensive scientific evidence for the use of dietary modification, and pro- and pre-biotics in preventing and intervening in chronic disease