Heteroaromatic Lipoxin A4 Analogues, 2012 Synthesis and Biological Evaluation Springer Theses Series
Auteur : Duffy Colm
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Nominated by University College Dublin as an outstanding PhD thesis
Author describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4
Description of an excellent route to a thiophene-containing LXA4 analogue
Includes supplementary material: sn.pub/extras
Date de parution : 02-2014
Ouvrage de 130 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 105,49 €
Ajouter au panierDate de parution : 01-2012
Ouvrage de 130 p.
15.5x23.5 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 105,49 €
Ajouter au panier