Genome Stability DNA Repair and Recombination

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

Chapter 1. Restarting DNA Replication by Recombination
Chapter 2. Double-strand Break Repair Pathways
Chapter 3. RecA/Rad51 and the Search for Homology
Chapter 4. Preparation of the RecA/Rad51 Filament
Chapter 5. Single-Strand Annealing
Chapter 6. Gene Conversion
Chapter 7. In vivo Biochemistry: Recombination in Yeast
Chapter 8. Break-induced Replication
Chapter 9. Sister Chromatid Repair
Chapter 10. Gene Targeting
Chapter 11. Site-specific Recombination
Chapter 12. Cytology and Genetics of Meiosis
Chapter 13. Molecular Events During Meiotic Recombination
Chapter 14. Holliday Junction Resolvases and Crossing-over
Chapter 15. Nonhomologous End-joining
Chapter 16. DNA Damage Checkpoints and Genome Instability