Gangliosides in Health and Disease Progress in Molecular Biology and Translational Science Series

Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field.

Preface and Ganglioside Nomenclature Ronald L Schnaar, Pablo H. H. Lopez 1. Ganglioside Metabolism in Health and Disease Roger Sandhoff, Heike Schulze, Konrad Sandhoff 2. Congenital Disorders of Ganglioside Biosynthesis T. August Li, Ronald L. Schnaar 3. Gangliosides in Membrane Organization Sandro Sonnino, Elena Chiricozzi, Sara Grassi, Laura Mauri, Simona Prioni, Alessandro Prinetti 4. Biological and Pathological Roles of Ganglioside Sialidases Taeko Miyagi, Kohta Takahashi, Koji Yamamoto, Kazuhiro Shiozaki, Kazunori Yamaguchi 5. Biology of GM3 Ganglioside Jin-ichi Inokuchi, Kei-ichiro Inamori, Kazuya Kabayama, Masakazu Nagafuku, Satoshi Uemura, Shinji Go, Akemi Suzuki, Isao Ohno, Hirotaka Kanoh, Fumi Shishido 6. Gangliosides in Cancer Cell Signaling Sophie Groux-Degroote, Macarena Rodríguez-Walker, Justine H. Dewald, Jose L. Daniotti, Philippe Delannoy 7. Gangliosides in Diabetic Wound Healing Duncan Hieu M. Dam, Amy S. Paller 8. Gangliosides in Nerve Cell Specification Yutaka Itokazu, Jing Wang, Robert K. Yu 9. Gangliosides in Inflammation and Neurodegeneration Koichi Furukawa, Yuhsuke Ohmi, Orie Tajima, Yuki Ohkawa, Yuji Kondo, Ji Shuting, Noboru Hashimoto, Keiko Furukawa 10. Glycan Chains of Gangliosides: Functional Ligands for Tissue Lectins (Siglecs/Galectins) Robert W. Ledeen, Jürgen Kopitz, José Abad-Rodriguez, Hans-Joachim Gabius 11. Protein Toxins that Utilize Gangliosides as Host Receptors Madison Zuverink, Joseph T. Barbieri 12. Gangliosides and Autoimmune Peripheral Nerve Diseases John A. Goodfellow, Hugh J. Willison 13. Gangliosides in Axon Stability and Regeneration Pablo H. H. Lopez, Bárbara B. Báez 14. Ganglioside-Mediated Assembly of Amyloid ß-Protein: Roles in Alzheimer’s Disease Katsumi Matsuzaki, Koichi Kato, Katsuhiko Yanagisawa 15. Gangliosides, a-Synuclein and Parkinson's Disease Robert W. Ledeen, Gusheng Wu

All biomedical researchers interested in enhancing their understanding of ganglioside functions.

• Contains accessible content that is ideal for students and researchers alike
• Written by leading authorities in the field