Forkhead FOXO Transcription Factors in Development and Disease

Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics.

This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism.

1. DAF-16: FOXO in the Context of C. elegans Heidi A. Tissenbaum 2. Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm Raymond Liang and Saghi Ghaffari 3. FOXOs Maintaining the Equilibrium for Better or for Worse Sabina van Doeselaar and Boudewijn M.T. Burgering 4. FOXO in Neural Cells and Diseases of the Nervous System Evan E. Santo and Jihye Paik 5. Regulation of Hepatic Glucose Metabolism by FOXO Proteins, an Integrated Approach Terry G. Unterman 6. The Role of FOXOs in Bone Health and Disease Ha-Neui Kim, Srividhya Iyer, Rebecca Ring and Maria Almeida 7. Regulation of FOXO Factors in Mammalian Cells Abigail K. Brown and Ashley E. Webb 8.FOXO3 and Exceptional Longevity: Insights From Hydra to Humans Philip M.C. Davy, Richard C. Allsopp, Timothy A. Donlon, Brian J. Morris, D. Craig Willcox and Bradley J. Willcox

Researchers in cell, molecular, developmental and evolutionary biology and in genetics

• Provides the authority and expertise of leading contributors
• Includes sections on the regulation of FOXO factors and stem cells
• Presents a unique view of this highly evolutionary family of transcription factors