Exosomes A Clinical Compendium
Coordonnateurs : Edelstein Lawrence R., Smythies John R., Quesenberry Peter J., Noble Denis
Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomesin the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medicaldisciplines, as well as their role in cell-cell communication. It is intended to serve as a referencesource for clinicians, physicians, and research scientists who wish to gain insight into the mostrecent advances in this rapidly growing field.
The exosome revolution may well be the greatest advance in physiology and medicine sinceantibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is amajor breakthrough in our understanding of how cells function.
1. Exosome Basic Mechanisms 2. Methods for exosome isolation and characterization 3. Exosomes, microvesicles, and their friends in solid tumors 4. Hematologic malignancies: the exosome contribution in tumor progression 5. Physiological and pathological functions of prostasomes: From basic research to clinical application 6. The function and therapeutic use of exosomes in bacterial infections 7. Emerging therapeutic roles of exosomes in HIV-1 infection 8. Extracellular vesicles in parasitic disease 9. Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases 10. Exosomes in Cutaneous Biology and Dermatologic Disease 11. Exosomes in Nephrology 12. Extracellular vesicles in neurodegenerative disorders 13. Extracellular vesicles in fibrotic diseases: New applications for fibrosis diagnosis and treatment 14. Mechanisms of exosome-mediated immune cell crosstalk in inflammation and disease 15. Exosomes in Metabolic Syndrome 16. Potential Role of Exosomes In Reproductive Medicine And Pregnancy 17. Exosomes in Respiratory Disease 18. Exosomes in Retinal Diseases 19. MSC-exosomes in regenerative medicine 20. The potential of exosomes as theragnostics in various clinical situations 21. Exosomes, Gemmules, Pangenesis and Darwin
Research scientists and clinicians across the disciplines noted in the sections below.
John Raymond Smythies, M.B. B.Chir., M.D., F.R.C.P., F.R.C. Psych. (1922-2019) was the Director of the Integrative Neuroscience Program in the Department of Psychology at the University of California San Diego. As a pre-eminent neuropsychiatrist and neuroscientist he made significant contributions to both these disciplines. Together with Humphry Osmond he developed the first biochemical theory of schizophrenia - the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal in schizophrenia. He made extensive contributions to knowledge in a number of fields including the neuropharmacology of psychedelic drugs; the functional neuroanatomy of synapses with particular regard to the role of synaptic plasticity, endocytosis and redox factors; the role in the brain of orthoquinone metabolites of catecholamines; and, in particular, theories of brain-consciousness relations. More recently he developed foundational hypotheses and theories specific to the f
- Provides readers with a broad and timely overview of exosomes in health and disease, closingwith a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck.
- Summarizes the most recent laboratory and clinical findings on exosomes across numerousmedical disciplines, thereby offering readers a broad-ranging and solid foundation for prospectiveinvestigative efforts
- Twenty-one chapters authored by a global team of peer-acknowledged experts, each representinga key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing
Date de parution : 10-2019
Ouvrage de 548 p.
15x22.8 cm
