Enzyme Handbook 4 Class 3: Hydrolases

Recent progress in enzyme immobilisation, enzyme production, coenzyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. As more progress in research and application of enzymes has been made the more apparent has become the Iack of an up-to-date overview of enzyme molecular properties. The need for such a data bank was also expressed by the EC-task force "Biotechnology and Information". Therefore we started the development of an enzyme data information system as part of protein-design activities at GBF. The present book "Enzyme Handbook" represents the printed version of this data bank. ln future it is also planned to make a com­ puter searchable version available. The enzymes in the Handbook are arranged according to the 1984 Enzyme Commission Iist of enzymes and later supplements. Same 3000 "different" en­ zymes are covered. Frequently very different enzymes are included under the same E. C. number. Although we intended to give a representative overview on the molecular variability of each enzyme, the Handbook is not a com­ pendium. The readerwill have to go to the primary Iiterature for more detailed information. Naturally it is not possible to cover all numerous, up to 40 000, Iiterature references for each enzyme if data representation is to be concise as is intended.

Alpha-amylase.- Beta-amylase.- Glucan 1, 4-alpha-glucosidase.- Cellulase.- Endo-1, 3(4)-beta-glucanase.- Inulinase.- Endo-1, 4-beta-xylanase.- Oligo-1, 6-glucosidase.- Dextranase.- Chitinase.- Polygalacturonase.- Lysozyme.- Sialidase.- Alpha-glucosidase.- Beta-glucosidase.- Alpha-galactosidase.- Beta-galactosidase.- Alpha-mannosidase.- Beta-mannosidase.- Beta-fructofuranosidase.- Alpha, alpha-trehalase.- N-Acetyl-beta-glucosaminidase.- Beta-glucuronidase.- Xylan endo-1, 3-beta-xylosidase.- Amylo-1, 6-glucosidase.- Hyaluronoglucosaminidase.- Hyaluronoglucuronidase.- Xylan 1, 4-beta-xylosidase.- Beta-D-fucosidase.- Glucan endo-1, 3-beta-glucosidase.- Alpha-L-rhamnosidase.- Alpha-dextrin endo-1, 6-alpha-glucosidase.- GDPglucosidase.- Beta-L-rhamnosidase.- Fucoidanase.- Glucosylceramidase.- Galactosylceramidase.- Galactosylgalactosylglucosylceramidase.- Sucrose alpha-glucosidase.- Alpha-N-acetylgalactosaminidase.- Alpha-N-acetylglucosaminidase.- Alpha-L-fucosidase.- Beta-N-acetylhexosaminidase.- Beta-N-acetylgalactosaminidase.- Cyclomaltodextrinase.- Alpha-L-arabinofuranosidase.- Glucuronosyl-disulfoglucosamine glucuronidase.- Isopullulanase.- Glucan 1, 3-beta-glucosidase.- Glucan endo-1, 3-alpha-glucosidase.- Glucan 1, 4-alpha-maltotetraohydrolase.- Mycodextranase.- Glycosylceramidase.- 1, 2-Alpha-L-fucosidase.- 2, 6-Beta-fructan 6-levanbiohydrolase.- Levanase.- Quercitrinase.- Galacturan 1, 4-alpha-galacturonidase.- Isoamylase.- Glucan 1, 6-alpha-glucosidase.- Glucan endo-1, 2-beta-glucosidase.- Xylan 1, 3-beta-xylosidase.- Lichenase.- Glucan 1, 4-beta-glucosidase.- Glucan endo-1, 6-beta-glucosidase.- L-lduronidase.- Mannan 1, 2-(1, 3)-alpha-mannosidase.- Mannan endo-1, 4-beta-mannosidase.- Fructan beta-fructosidase.- Agarase.- Exo-poly-alpha-galacturonosidase.- Kappa-carrageenase.- Glucan 1, 3-alpha-glucosidase.- 6-Phospho-beta-galactosidase.- 6-Phospho-beta-glucosidase.- Capsular-polysaccharide endo-1, 3-alpha-galactosidase.- Beta-L-arabinosidase.- Arabinogalactan endo-1, 4-beta-galactosidase.- Arabinogalactan endo-1, 3-beta-galactosidase.- Cellulose 1, 4-beta-cellobiosidase.- Peptidoglycan beta-N-acetylmuramidase.- Alpha, alpha-phosphotrehalase.- Glucan 1, 6-alpha-isomaltosidase.- Dextran 1, 6-alpha-isomaltotriosidase.- Mannosyl-glycoprotein endo-beta-N-acetyl glucosaminidase.- Glycopeptide alpha-N-acetylgalactosaminidase.- Glucan 1, 4-alpha-maltohexaosidase.- Arabinan endo-1, 5-alpha-L-arabinosidase.- Mannan 1, 4-beta-mannobiosidase.- Mannan endo-1, 6-beta-mannosidase.- Blood-group-substance endo-1, 4-beta-galactosidase.- Keratan-sulfate endo-1, 4-beta-galactosidase.- Steryl-beta-glucosidase.- Strictosidine beta-glucosidase.- Mannosyl-oligosaccharide glucosidase.- Protein-glucosylgalactosylhydroxylysine glucosidase.- Lactase.- Endogalactosaminidase.- Mucinaminylserine mucinaminidase.- Purine nucleosidase.- Inosine nucleosidase.- Uridine nucleosidase.- AMP nucleosidase.- NAD+ nucleosidase.- NAD(P)+ nucleosidase.- Adenosine nucleosidase.- Ribosylpyrimidine nucleosidase.- Adenosylhomocysteine nucleosidase.- Pyrimidine-5’-nucleotide nucleosidase.- Beta-aspartyl-N-acetylglucosaminidase.- Inosinate nucleosidase.- 1-Methyladenosine nucleosidase.- NMN nucleosidase.- DNA-deoxyinosine glycosidase.- Methylthioadenosine nucleosidase.- Deoxyribodipyrimidine endonucleosidase.- ADPribosylarginine hydrolase.- Thioglucosidase.- Asparaginase.- Glutaminase.- Omega-amidase.- Amidase.- Urease.- Beta-ureidopropionase.- Ureidosuccinase.- Formylaspartate deformylase.- Arylformamidase.- Formyltetrahydrofolate deformylase.- Penicillin amidase.- Biotinidase.- Aryl acylamidase.- Aminoacylase.- Aspartoacylase.- Acetylornithine deacetylase.- Acyl-lysine deacylase.- Succinyldiaminopimelate desuccinylase.- Nicotinamidase.- Citrullinase.- N-Acetyl-beta-alanine deacetylase.- Pantothenase.- Acylsphingosine deacylase.- Cholylglycine hydrolase.- N-Acetylglucosamine-6-phosphate deacetylase.- N4-(Beta-N-acetylglucosaminyl)-L-asparaginase.- N-Formylmethionylaminoacyl-tRNA deformylase.- N-Acetylmuramoyl-L-alanine amidase.- 2-(Acetamidomethylene)succinate hydrolase.- 5-Aminopentanamidase.- Formylmethionine deformylase.- Hippurate hydrolase.- N-Acetylglucosamine deacetylase.- D-Glutaminase.- N-Methyl-2-oxoglutaramate hydrolase.- Glutamin-(asparagin-)ase.- Alkylamidase.- Acylagmatine amidase.- Chitin deacetylase.- Nicotinamide-nucleotide amidase.- Peptidyl-glutaminase.- Protein-glutamine glutaminase.- Urease (ATP-hydrolysing).- 6-Aminohexanoate-dimer hydrolase.- Acetyldiaminopimelate deacetylase.- Acetylspermidine deacetylase.- Formamidase.- Pentanamidase.- 4-Acetamidobutyryl-CoA deacetylase.- Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase.- Barbiturase.- Dihydropyrimidinase.- Dihydroorotase.- Carboxymethylhydantoinase.- Allantoinase.- Beta-lactamase.- Imidazolonepropionase.- 5-Oxoprolinase (ATP-hydrolysing).- Creatininase.- L-Lysine-lactamase.- 6-Aminohexanoate-cyclic-dimer hydrolase.- Arginase.- Glycocyaminase.- Creatinase.- Allantoicase.- Formiminoaspartate deiminase.- Arginine deiminase.- Guanidinobutyrase.- Formiminoglutamase.- Allantoate deiminase.- D-Arginase.- Agmatinase.- Agmatine deiminase.- Formiminoglutamate deiminase.- Amidinoaspartase.- Protein-arginine deiminase.- Methylguanidinase.- Cytosine deaminase.- Adenine deaminase.- Guanine deaminase.- Adenosine deaminase.- Cytidine deaminase.- AMP deaminase.- ADP deaminase.- Aminoimidazolase.- Methenyltetrahydrofolate cyclohydrolase.- IMP cyclohydrolase.- Pteridin deaminase.- dCMP deaminase.- dCTP deaminase.- Deoxycytidine deaminase.- Guanosine deaminase.- GTP cyclohydrolase I.- Adenosine-phosphate deaminase.- ATP deaminase.- Phosphoribosyl-AMP cyclohydrolase.- Pyrithiamin deaminase.- Creatinine deiminase.- 1-Pyrroline-4-hydroxy-2-carboxylate deaminase.- Blasticidin-S deaminase.- Sepiapterin deaminase.- GTP cyclohydrolase II.- Diaminohydroxyphosphoribosylaminopyrimidine deaminase.- Nitrilase.- Ricinine nitrilase.- Cyanate hydrolase.- Riboflavinase.- Thiaminase.- Oxalacetase.- Fumarylacetoacetase.- Kynureninase.- Phloretin hydrolase.- Acylpyruvate hydrolase.- Acetylpyruvate hydrolase.- Alkylhalidase.- 2-Haloacid dehalogenase.- Haloacetate dehalogenase.- Thyroxine deiodinase.- Diisopropyl-fluorophosphatase.- Phosphoamidase.- N-Sulfoglucosamine sulfohydrolase.- Cyclamate sulfohydrolase.- Phosphonoacetylaldehyde hydrolase.