Chemogenomics in drug discovery. A medicinal chemistry perspective (Methods & principles in medicinal chemistry 22)

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Introduction. GENERAL ASPECTS. Target Family-directed Masterkeys. Drug Discovery from Side Effects. Chemical Genetics in Drug Discovery. Structural Aspects of Binding Site Similarity. TARGET FAMILIES. Knowledge-based Discovery of Biological Targets. Chemical Kinomics. Kinase Inhibitors. Ion Channel Modulators. Phosphodiesterase Inhibitors. Proteochemometrics. CHEMICAL LIBRARIES. Compound Library and Template Design for GPCRs. Computational Filters in Lead Generation. Ligand-based Design of Focused Libraries. Natural Product-derived Combinatorial Libraries. Combinatorial Chemistry in the Chemical Genomics Age.