Catalytic antibodies

Exploiting the inherent combinatorial mechanism in the biosynthesis of antibodies, an almost limitless variety of biocatalysts may be generated. Catalytic antibodies are capable of performing almost any type of reaction with high selectivity and stereospecificity. Here, the pioneers in the use of catalytic antibodies review the entire scope of this interdisciplinary field, covering such topics as: theoretical aspects of structure, mechanism and kinetics, practical considerations, from immunization techniques to screening methods, in vitro evolution and other modern approaches, applications from organic synthesis to medical uses. Backed by the leading authorities in antibody catalysis, this is the first book to provide such comprehensive coverage and will be the prime reference for biochemists, organic chemists, biotechnologists and biomedical researchers.

The immunological evolution of catalysis. Mechanistic considerations and concerted reactions. Theoretical studies of antibody catalysis. Catalytic antibodies - historical perspective. Catalytic antibodies in organic synthesis. Structure and function of catalytic antibodies. Antibody-catalyzed disfavored reactions. Immunization techniques and screening methods. In vitro evolution of catalytic antibodies. Medicinal applications of catalytic antibodies. Reactive immunization and aldolase antibodies. Antibody-catalyzed oxidation processes. Antibody-catalyzed photochemical reactions. Stereoselective processes with catalytic antibodies. Conformational effects in antibody catalysis. Transition state analogues and antibody catalysis. Polyclonal catalytic antibodies. Production of monoclonal catalytic antibodies. Natural catalytic antibodies.