Lavoisier S.A.S.
14 rue de Provigny
94236 Cachan cedex

Heures d'ouverture 08h30-12h30/13h30-17h30
Tél.: +33 (0)1 47 40 67 00
Fax: +33 (0)1 47 40 67 02

Url canonique :
Url courte ou permalien :

Calcium Entry Pathways in Non-excitable Cells, 1st ed. 2016 Advances in Experimental Medicine and Biology Series, Vol. 898

Langue : Anglais

Coordonnateur : Rosado Juan A.

Couverture de l’ouvrage Calcium Entry Pathways in Non-excitable Cells
Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.

Part I Store-operated calcium entry

1.      Historical overview of store-operated Ca2+  entry - Letizia Albarran, Jose J Lopez, Ginés M. Salido and Juan A. Rosado

2.      The STIM1- Orai interaction- Irene Frischauf, Marc Fahrner, Isaac Jardin-Polo and Christoph Romanin

3.      The TRPCs, Orais and STIMs in ER/PM junctions- Dong Min Shin, Aran Son, Seonghee Park, Min Seuk Kim, Malini Ahuja, and Shmuel Muallem

4.      The TRP-Na-Ca2+ exchanger coupling- Alan G.S. Harper and Stewart O. Sage

5.      Role of TRPC channels in store-operated calcium entry- Hwei Ling Ong, Lorena Brito de Souza and Indu S. Ambudkar

6.      Phospholipase A2 as a molecular determinant of store-operated calcium entry- Tarik Smani, Alejandro Domínguez-Rodriguez, Paula Callejo-García, Juan A. Rosado, Javier Avila-Medina

7.      Extracellular calcium has multiple targets to control cell proliferation- T Capiod

8.      Regulation of platelet function by Orai, STIM and TRP- Alejandro Berna-Erro, Isaac Jardín, Tarik Smani and Juan A. Rosado

Part II Non-capacitative Ca2+ entry pathways

9.      On the roles of the Transient Receptor Potential Canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis - Guillermo Vazquez, Sumeet Solanki, Prabhatachandra Dube, Kathryn Smedlund, Prince Ampem

10.  Second messenger-operated calcium entry through TRPC6- Alexandre Bouron, Sylvain Chauvet, Stuart Dryer, Juan A. Rosado

11.  Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Nonselective Cation Channel- Xuexin Zhang, Amy M. Spinelli, Timothy Masiello, Mohamed Trebak

12.  Calcium entry through thermosensory channels- Francisco J Taberner, Isabel Devesa and Antonio Ferrer-Montiel

13.  Calcium signalling through ligand-gated ion channels such as P2X1 receptors in the platelet and other non-excitable cells - Martyn P. Mahaut-Smith, Kirk A. Taylor and Richard J. Evans

Part III Role of cellular microdomains and organelles in calcium entry

14.  The calcium entry-calcium refilling coupling- Ziane Elaib, Francois Saller and Regis Bobe

15.  Microdomains associated to lipid rafts- Jonathan Pacheco, Josué O. Ramírez-Jarquín, and Luis Vaca

16.  Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry- B Constantin

17.  Modulation of calcium entry by mitochondria- Rosalba Fonteriz, Jessica Matesanz-Isabel, Jessica Arias-del-Val, Pilar Alvarez-Illera, Mayte Montero and Javier Alvarez

18.  Modulation of calcium entry by the endo-lysosomal system- G. Cristina Brailoiu1 and Eugen Brailoiu

19.  Remodeling of calcium entry pathways in cancer- Carlos Villalobos, Diego Sobradillo, Miriam Hernández-Morales and Lucía Núñez


Provides an extensive overview of the mechanisms underlying calcium entry in non-excitable cells

Includes relevant background information, critical analysis of the current observations and directions for future research

Written in a concise manner by leading scientists in the field

Date de parution :

Ouvrage de 471 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 168,79 €

Ajouter au panier

Date de parution :

Ouvrage de 471 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

168,79 €

Ajouter au panier

Thèmes de Calcium Entry Pathways in Non-excitable Cells :

Ces ouvrages sont susceptibles de vous intéresser

En continuant à naviguer, vous autorisez Lavoisier à déposer des cookies à des fins de mesure d'audience. Pour en savoir plus et paramétrer les cookies, rendez-vous sur la page Confidentialité & Sécurité.