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Biology of Oral Cancer Key Apoptotic Regulators

Langue : Anglais

Auteurs :

Couverture de l’ouvrage Biology of Oral Cancer

Cancer is a class of disease or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues. One new approach in dealing with cancer is through apoptotic regulators, which is the process of controlling cell growth by abnormally prolonging cell survival, facilitating the accumulation of transforming mutations and promoting resistance. This book uses oral cancers as the specific means to demonstrate this technique with this particular type of cancer, which is quite prevalent (and deadly) in India and other parts of Asia, in particular.

Cancer: A Worldwide Menace

Epidemiology

Diagnosis and Pathology

Conclusion

References

Oral Cancer

Key Words

Introduction

Epidemiology

Signs and Symptoms

Sex and Age Distribution

Etiology

Pathology

Staging

Individual Cancers of the Oral Cavity

Conclusion

References

Proliferative and Apoptotic Signaling in Oral Cancer

Key Words

Introduction

Regulation of Cell Homeostasis

Somatic Gene Mutation

Oncogenes and Tumor Suppressors

NF-κB

Serine/Threonine Kinases

Steroid Hormones

Central Role of Caspases

Caspases Inhibitory Proteins

Death Domains

Fas/Fas Ligand

TRAIL and Its Receptors

Conclusion

References

Apoptotic Regulations

Key Words

Introduction

Etymology

Mechanisms of Apoptosis in Cancer

Role of Apoptotic Regulators in Rheumatoid Arthritis (RA)

Role of Apoptotic Regulators in Prostate Carcinoma

Conclusion

References

Dynamics of p53 in Oral Cancer

Key Words

Introduction

Functions and Roles in Causing Disease

p53 as an Oncogene

p53 as a Tumor Suppressor

Mutations in p53

Apoptotic Regulation by p53

Interplay between Survivin and p53

Clinicopathological Significance of p53

Therapeutic Strategies Targeting p53

Conclusion

References

Diagnostic and Therapeutic Potential of Apoptotic Marker

Key Words

Introduction

Apoptotic Markers in Oral Cancer Therapeutics

Apoptotic Markers in Oral Cancer Diagnostics

Conclusion

References

Expression and Regulation of Survivin

Key Words

Introduction

Molecular Organization and Structure of Survivin

Functions of Survivin

Regulation of Survivin

Anti-Apoptotic Network of Survivin

Expression of Survivin in Normal Tissues

Expression of Survivin in Human Cancer

Conclusion

References

Therapeutics of Survivin

Key Words

Introduction

Manipulation of the Survivin Gene

Factors Inducing Survivin Expression

Downregulation of Survivin

Ribozyme-Mediated Degradation of Survivin

Immunotherapy

Therapeutic Biology of Survivin

Survivin-Directed Cancer Therapy

Regulation of Survivin in Head and Neck Squamous Carcinoma

Prognostic and Diagnostic Significance of Survivin

Therapeutic Approach

Survivin for Cancer Immunotherapy

Conclusion

References

Molecular Diagnosis of Oral Cancer

Key Words

Introduction

Molecular Markers for Oral Cancer

Molecular Mechanism of Development of Oral Cancer

The Hallmarks of Oral Cancer

Other Markers

Diagnosis of Oral Squamous Cell Carcinoma

Conclusion

References

Glossary

Index

Date de parution :

15.6x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 13 jours).

Prix indicatif 69,51 €

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Date de parution :

Ouvrage de 268 p.

15.6x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 13 jours).

Prix indicatif 130,70 €

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