Biological Barriers to Protein Delivery, Softcover reprint of the original 1st ed. 1993 Pharmaceutical Biotechnology Series, Vol. 4

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

I. Cellular Barriers.- 1 The Paracellular Pathway: A Small Version of the Kidney Nephron.- 2 Ectopeptidases.- 3 Endosomal and Lysosomal Hydrolases.- 4 Protein Uptake and Cytoplasmic Access in Animal Cells.- II. Epithelial Barriers.- 5 Transepithelial Transport of Proteins by Intestinal Epithelial Cells.- 6 Intraoral Peptide Absorption.- 7 Macromolecular Transport across Nasal and Respiratory Epithelia.- 8 Dermal Absorption of Peptides and Proteins.- 9 Rectal and Vaginal Absorption of Peptides and Proteins.- III. Vascular Barriers.- 10 Vascular Endothelial Barrier and Its Regulation.- 11 Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers in Vivo.- IV. Elimination Barriers.- 12 Renal Uptake and Disposal of Proteins and Peptides.- 13 Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins: Implications for Rate of Elimination, Bioavailability, and Cell-Specific Drug Delivery to the Liver.- 14 The Immune System as a Barrier to Delivery of Protein Therapeutics.- V. Tissue Barriers.- 15 Extravasation and Interstitial Transport in Tumors.- 16 Tissue Barriers: Diffusion, Bulk Flow, and Volume Transmission of Proteins and Peptides within the Brain.