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A Systems Theoretic Approach to Systems and Synthetic Biology II, Softcover reprint of the original 1st ed. 2014 Analysis and Design of Cellular Systems

Langue : Anglais

Coordonnateurs : Kulkarni Vishwesh V., Stan Guy-Bart, Raman Karthik

Couverture de l’ouvrage A Systems Theoretic Approach to Systems and Synthetic Biology II
Recent advances in systems and synthetic biology clearly demonstrate the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. So far, state-of-the-art systems-and-control-theory-inspired results in systems and synthetic biology have been scattered across various books and journals from various disciplines. This edited book provides a panoramic view and illustrates the potential of such systematic and rigorous mathematical methods in systems and synthetic biology. The book-chapters demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in our quest to understand how biological systems function and/or how they can be (re-)designed from the bottom-up to yield new biological systems that have rigorously characterised robustness and performance properties. The book presents 24 book chapters contributed by leading researchers in systems and synthetic biology that illustrate how biologists as well as systems and control theorists can collaborate to make deep and timely contributions in interdisciplinary life science research on how to devise experiments to obtain models of biological systems, how to obtain predictive models using information extracted from experimental data, how to choose components for (re-)engineering biological networks, how to adequately interconnect biological systems and so on. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.


1 Network Biomarker Construction for Molecular Investigation and Diagnosis of Lung Cancervia Microarray Data
Yu-Chao Wang and Bor-Sen Chen

2 The Impact of Next Generation Sequencing Technology on Bacterial Genomics
Avantika Lala and Aswin Sai Narayan Seshasayee

3 Sensitivity Analysis of Circadian Entrainment in the Space of Phase Response Curves
Pierre Sacr ́e and Rodolphe Sepulchre

4 Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast
Francesco Montefusco, Ozgur E. Akman, Orkun S. Soyer, and Declan G. Bates

5 Analysis of Synchronizing Biochemical Networks via Incremental Dissipativity
Abdullah Hamadeh, Jorge Gonc ̧alves, and Guy-Bart Stan

6 Robustness Model Validation of Bistability in Biomolecular Systems
Luca Salerno, Carlo Cosentino, Alessio Merola, Declan G. Bates, and Francesco Amato

7 Meta-DNA: A DNA-Based Approach to Synthetic Biology
Harish Chandran, Nikhil Gopalkrishnan, Bernard Yurke, and John Reif

8 Towards Modeling Automation for Synthetic Biology
 Chen Liao and Yizhi Cai

9 An Investigation of Signal Transduction and Irreversible Decision Making through Monostable and Bistable Switches
J. Krishnan and C. Liu

10 From Specification to Parameters: A Linearization Approach
Heinz Koeppel, Marc Hafner and James Lu

11 Simplified Computational Design of Digital Synthetic Gene Circuits Mario Andrea Marchisio and J ̈org Stelling

12 Synthetic Biochemical Devices for Programmable Dynamic Behavior
Jongmin Kim and Elisa Franco


New rigorous methods to obtain better predictive models of biological networks

New results on the limits of performance in biological networks

Includes novel applications of in vitro synthetic biology in nanotechnology

Date de parution :

Ouvrage de 298 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

Prix indicatif 138,03 €

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Date de parution :

Ouvrage de 298 p.

15.5x23.5 cm

Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).

168,79 €

Ajouter au panier
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