Computational and Experimental Studies in Alzheimer's Disease

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer?s disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer?s disease.

Key features:

• Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer?s agents
• Explains the role of phytomolecules and natural products in Alzheimer?s therapy
• Reviews preclinical ways to assess drugs focusing on Alzheimer?s disease
• Covers biomarker analysis for Alzheimer?s disease
• Discusses the onset and progression of Alzheimer?s disease

The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

Chapter 1: Alzheimer's Disease: Epidemiology, Neuropathology, and Neurochemistry

Raushan Kumar Chaudhary, Uday Venkat Mateti, Pukar Khanal, Kala Bahadur Rawal, Praneetha Jain, Vishal S Patil, Amit Kumar Shrivastava and B M Patil

Chapter 2: Preclinical Approach: In vivo and In vitro Methods for Evaluation of Anti-Alzheimer's Drugs

Nilutpal Sharma Bora, Bhargab Jyoti Sahariah, Chanam Melody Devi and Banshongdor H. Mawlieh

Chapter 3: Computational Insights into the Applications of Plant-Based Therapies in Alzheimer's Disease

Dibyajyoti Das, Satyendra Deka, Biswajit Devanath, Aparoop Das, Nongmaithem Randhoni Chanu and Ramen Kalita

Chapter 4: Advances in Applying Computer-Aided Drug Design for Alzheimer’s Disease

Biswajit Devanath, Satyendra Deka, Dibyajyoti Das, Hans Raj Bhat, Nongmaithem Randhoni Chanu and Kunal Bhattacharya

Chapter 5: Biomarkers Analysis for Alzheimer's Disease

Shraddha M. Jadhav and Karan Kumar

Chapter 6: Mechanistic Aspects of Neurodegeneration in Alzheimer's Disease and the Role of Phytochemicals

Trideep Saikia, Tutumoni Kalita, Bhanu P Sahu, Prakash Rajak, Bhargab Deka and Alakesh Bharali

Chapter 7: Computational Modelling of BACE-1, AChE, and Phosphodiesterase Inhibitors as Anti-Alzheimer's Agents

Vishal S Patil, Jagadeesh Dodakallanavar, Pukar Khanal, B M Patil, Raushan K Chaudhary, Amit Kumar Shrivastava, Nongmaithem Randhoni Chanu, Darasaguppe R. Harish and Uday Venkat Mateti

Chapter 8: Therapeutic Application of Natural Products in Alzheimer’s Disease Using Computational Methods

Muhammad Aqib Shabbir, Muhammad Naveed, Maleeha Manzoor, Hafiz Muhammad Hurraira, Noor-ul-Ain and Fatima Zaidi

Chapter 9: Analysis of Potential Alzheimer's Disease Inhibitors Based on Computational Modelling with Multiple Targets

Ankita Dubey, Vrishti M Thakur, Raja Chakraborty, G.N. Darwhekar, Rupesh Kushwah and Rakhi Khabiya

Chapter 10: Virtual Screening: Pioneering the Future of Drug Discovery in Alzheimer's Disease

N. Yellasubbaiah, B. Sivakumar and B. Nagasudha

Index

Kunal Bhattacharya is currently working as assistant professor in Pratiksha Institute of Pharmaceutical Sciences, Assam, India. His area of specialization includes Computer aided drug design, Bioinformatics and Analytical Chemistry. He obtained his M.Pharm in Pharmaceutical Chemistry from Nitte University, Mangalore, India. He is currently pursuing his PhD in pharmaceutical sciences in neurodegenerative diseases from The Assam Royal Global University, Assam, India.

Atanu Bhattacharjee is currently working as a professor at School of Pharmacy, The Assam Royal Global University, Assam, India. He is considered as pioneer in the field of pharmacognosy and phytochemistry. Dr. Bhattacharjee achieved his Ph.D in Pharmaceutical Sciences in the areas of phytochemistry and neuro-pharmacology from Nitte University, Mangalore, India. He worked extensively on various in silico, in vitro and in vivo experiments to encounter neuro-degenerative disorders like Alzheimer’s disease with folklore medicine from the Indian diaspora and to determine safety profiles and standardize medicinal plants.