Malignancies of the Nasal Vestibule, 1st ed. 2023 A New Perspective on Classification, Staging, and Treatment

This book provides up-to-date information on nasal vestibule malignancies, outlining the specific clinical history and pattern of spread. It also describes the flaws in TNM staging, which can be attirbuted to factors ranging from the anatomy to the definition of the main prognostic parameters.

Nasal vestibule malignancies are associated with a peculiar oncological history, but there are also clear issues related to the reconstructive phase following ablative surgery due to the anatomic peculiarities.  Such issues deeply impact the cosmetic and functional results, and hence the quality of life of surviving patients.

Additionally, the book describes novel evidence on treatment outcomes for these malignancies in terms of both oncological and functional results. It proposes a new standard based on interstitial HDR brachytherapy for the primary lesion and on surgery for regional metastases.

The book appeals to a wide readership, ranging from otolaryngologists, to radiation and clinical oncologists, dermatologists, plastic surgeons and maxillo-facial surgeons.

Functional and surgical anatomy of the nose vestibule.- Histology of nose vestibule malignancy.- Peculiar patterns of spread of nose vestibule malignancies.- Subsites in the nose, the WHO classification and the current 8^th edition of AJCC/UICC TNM in the staging of nose vestibule malignancies.- Current misclassification of nose vestibule malignancies: need for the definition of nose vestibule as a subsite in the nose/paranasal cavities with a specific T classification.- Diagnostic work up of nose vestibule malignancies.- Current therapeutic options in nose vestibule malignancies.- Surgery in nose vestibule malignancies: the demolitive phase.- Surgery in nose vestibule malignancies: the reconstructive phase.- Surgery in nose vestibule malignancies: prostheses.- External beam radiotherapy for nose vestibule malignancies.- Brachytherapy for nose vestibule malignancies: oncological results.- Brachytherapy for nose vestibule malignancies: functional results.- Implantation technique in nose vestibule malignancies: learning from rhinoseptoplasty, beyond the Paris system.- Brachytherapy for nose vestibule malignancies: treatment planning beyond the Paris system.- Combined approaches and other treatment modalities.- Managing the neck in nose vestibule malignancies.- A new standard for the treatment of nose vestibule malignancies.

Francesco Bussu is currently a Professor and Chairman in Otolaryngology, as well as the Head of the ENT Division at the University Hospital of Sassari (Italy). He reactivated the Sassari Speech Therapy School in 2020. He is a member of the Italian commission for National Scientific Qualification to Professorship and the treasurer of the Italian Society of Otorhinolaryngology (SIO).

He performed about 10,000 surgical procedures as first operator in all the subspecialties of otolaryngology, and in particular head and neck oncology. He introduced the lengthening temporalis myoplasty (Labbè operation) in Italy for long-term facial paralysis rehabilitation, and he has performed over 100 brachytherapy implants for head and neck malignancies, more than 50 for nasal vestibule primaries. He has contributed to clarifying the oncogenic role of HPV in non-oropharyngeal head and neck malignancies, and the clinical limits of the currently employed p16 IHC in the definition of HPV related carcinogenesis in the oropharynx.

He has published over 120 papers in indexed  journals, mainly on head and neck surgery and oncology and serves as a reviewer for several leading international journals.