Chesley's Hypertensive Disorders in Pregnancy (5th Ed.)
Coordonnateurs : Taylor Robert N., Conrad Kirk P., Davidge Sandra T., Staff Anne Cathrine, Roberts James M.
Leon Chesley?s Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley?s Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.
1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy
2. Epidemiology of Pregnancy-Related Hypertension
3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia
4. Preconceptional and Periconceptional Pathways to Preeclampsia
5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies
6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome
7. The Immunology of Preeclampsia
8. Trophoblast Extracellular Vesicles in Preeclampsia
9. Angiogenesis and Preeclampsia
10. Vascular Endothelial Cell Dysfunction in Preeclampsia
11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
12. Cardiometabolic Antecedents of Preeclampsia
13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia
14. The Kidney in Normal Pregnancy and Preeclampsia
15. Salt, Aldosterone, and the Renin— Angiotensin System in Pregnancy
16. Platelets, Coagulation, and the Liver
17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy
18. Prediction and Prevention of Preeclampsia
19. Long-Term Effects of Preeclampsia on Mothers and Offspring
20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets
21. Harmonization of Data and Biobanks for Preeclampsia Research
Dr. Conrad has had a longstanding research interest in the hormonal, cellular and molecular mechanisms underlying maternal renal and systemic vasodilation, and increased arterial compliance during normal pregnancy with emphasis on the ovarian hormone, relaxin. More recently, he has been PD/PI of a NIH Program Project Grant designed to explore maternal pregnancy physiology and outcome in women conceiving through in vitro fertilization with focus on the contribution of the corpus luteum. Finally, Dr. Conrad has been exploring a role for dysregulated (pre)decidualization in the genesis of preeclampsia, and in the larger context of “endometrium spectrum disorders. Dr. Conrad has combined preclinical and clinical research throughout his career to translate findings in animal models, tissues and cells to humans or vice versa. The main disease focus of his pregnancy research has been preecla
- Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date
- Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
- Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists
Date de parution : 12-2021
Ouvrage de 486 p.
21.5x27.6 cm
Thème de Chesley's Hypertensive Disorders in Pregnancy :
Mots-clés :
Acute kidney injury; Altered DNA methylation; Angiogenesis; Animal models; Antihypertensive drugs; Antiphospholipid syndrome; Aspirin; Biomarkers; Cardiometabolic risk; Cardiovascular; Cardiovascular system; Chronic renal insufficiency; Classification; Complex disease; Corpus luteum; Cyclooxygenase; Cytotrophoblast; Cytotrophoblastic shell; Data sharing; Decidualisation; Decidualization; Developmental Origins of Health and Disease (DOHaD); Differential diagnosis; Dyslipidemia; Eclamptic fits; Endoplasmic reticulum stress; Epidemiology; Epigenetic alterations; Epigenome; Exome and genome sequencing; Exosomes; Extracellular vesicles; Extravillous trophoblast; Genetic models; Genetics; Genomics; Global collaboration; Glomerular Endotheliosis; Glomerular endotheliosis; Glomerular filtration; Harmonization of data collections in preeclampsia research; Harmonization of preeclampsia biobanking; HELLP syndrome; Hemodynamics; History; Histotrophic nutrition; Human leukocyte antigen (HLA); Human placenta; Hypertension