Pediatric Acute Lymphoblastic Leukemia, 1st ed. 2020

This book discusses key aspects of childhood acute lymphoblastic leukemia (ALL), presenting the latest research on the biology and treatment of the disease and related issues. The cure rate for ALL has improved dramatically due to advances such as supportive care, treatment strati?cation based on relapse risk, and the optimization of treatment regimens.

Gathering contributions by eminent scholars Pediatric Acute Lymphoblastic Leukemia is a valuable resource for pediatric hematologists as well as for medical students, interns, residents and fellows. It not only offers comprehensive insights, but also provides a springboard for future research.

Part I Epidemiology and Diagnosis of Pediatric ALL.- 1 Overview.- 2 Genetic alterations of pediatric acute lymphoblastic leukemia.- 3 Germline biology of pediatric ALL.- 4 Immunophenotype of pediatric ALL.- 5 MRD in pediatric ALL.- Part II Treatment of Pediatric ALL.- 6 B-cell precursor ALL.- 7 Pediatric T-cell acute lymphobastic leukemia.- 8 Mature B-cell acute lymphoblastic leukemia.- 9 Infant ALL.- 10 Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.- 11 Acute lymphoblastic leukemia in Down syndrome.- 12 Adolescents and young adults with acute lymphoblastic leukemia.- 13 Relapsed pediatric ALL.- 14 Ambiguous lineage acute leukemia (ALAL).- 15 Stem cell transplantation for pediatric ALL.- Part III Supporting Issues in Pediatric ALL.- 16 Supporting therapy.- 17 Late effects in pediatric acute lymphoblastic leukemia.